非甲状腺疾病综合征对儿童甲状腺功能的影响和预后

Effect of non-thyroidal illness syndrome on thyroid function and its prognosis in children

非甲状腺自身疾病的一些全身性疾病也可导致人体内甲状腺激素水平发生变化,称为非甲状腺疾病综合征(NTIS),其在儿童及成人中均可发生,儿童多见于新生儿、手术、重症监护室及遗传性疾病患者。脱碘酶活性、下丘脑-垂体-甲状腺轴、甲状腺激素结合蛋白、转运体、炎性因子及氧化应激等因素在NTIS的产生过程中起重要作用。NTIS预后往往具有适应性和自限性,关于疾病期间是否补充甲状腺激素的治疗目前仍存在争议,需进一步研究。

Some systemic diseases also can cause changes in thyroid hormone levels in the human body, called the non-thyroidal illness syndrome (NTIS), which occur in both children and adults.NTIS is more common in neonates, surgical patients, patients at intensive care unit and patients with genetic disease patients.Deiodinase activity, hypothalamic-pituitary-thyroid axis, thyroid hormone transporters, serum binding proteins, nuclear thyroid hormone receptors, cytokines, and oxidative stress are factors for developing NTIS.The prognosis of NTIS is often adaptive and self-limiting.The treatment of thyroid hormone supplementation during the disease needs further study.