头孢哌酮-舒巴坦钠对肺癌患者术后感染的疗效及其对炎症因子水平的影响

Efficacy of Cefoperazone Sulbactam in Postoperative Infection in Patients with Lung Cancer and Influence on Inflammatory Factors Level

目的:比较和评价头孢哌酮-舒巴坦钠与头孢呋辛对肺癌患者术后感染的疗效及其对炎症各因子水平的影响。方法:选取2016年1月—2018年11月间收治的肺癌患者术后感染86例资料,按照治疗方法的不同将其分为观察组和对照组,每组43例;观察组患者给予头孢哌酮-舒巴坦钠静脉滴注治疗,对照组患者则给予头孢呋辛静脉滴注治疗,比较两组患者治疗后的总有效率、临床症状(体温、痰中血丝、咳嗽及肺部啰音)复常时间的差异,以及治疗后炎症因子(IL-1、TNF-α、PCT、CRP)水平测得值的变化情况。结果:观察组患者治疗后的总有效率高于对照组(P<0.05),临床症状(体温、痰中血丝、咳嗽及肺部啰音)复常时间无早于对照组(P<0.05),炎症因子(IL-1、TNF-α、PCT、CRP)水平测得值均低于对照组(P<0.05),而IL-4、IL-10水平测得值均高于对照组(P<0.05)。结论:采用头孢哌酮-舒巴坦钠静脉滴注治疗肺癌患者术后感染的疗效优于头孢呋辛,有效改善了血清炎症因子水平,促进了临床症状的恢复。

Objective: To compare and evaluate the effects of cefoperazone sulbactam sodium and cefuroxime on postoperative infection in patients with lung cancer and its influence on the levels of inflammatory factors. Methods:Data of 86 cases of postoperative infection of lung cancer patients admitted from January 2016 to November 2018 were selected and divided into observation group and control group according to different treatment methods, with 43 cases in each group. Observation group patients were given cefoperazone sulbactam sodium intravenous drip treatment and control group patients were given cefuroxime intravenous drip treatment. The differences in the recovery time of clinical symptoms(body temperature, bloody sputum, cough and lung rale), and changes in the levels of inflammatory cytokines(IL-1, TNF-α, PCT, CRP) after treatment were compared. Results: In observation group of patients after treatment the total effective rate was higher than that of control group(P<0.05) and clinical symptoms(body temperature,blood in phlegm and cough and lung’s) recovery time were earlier than the control group(P<0.05), inflammatory cytokines(IL-1, TNF-α, PCT and CRP) levels measured values were lower than those of the control group(P<0.05), while IL-4, IL-10 levels measured values were higher than those of the control group and there was significant difference(P<0.05). Conclusion: The efficacy of cefoperazone sulbactam sodium intravenous infusion in the treatment of postoperative infection in patients with lung cancer is superior to that of cefuroxime, it effectively improves the level of serum inflammatory factors and promotes the recovery of clinical symptoms.