系统性红斑狼疮合并桥本氏甲状腺炎的临床分析

Clinical analysis of systemic lupus erythematosus with Hashimoto's thyroiditis

目的:研究系统性红斑狼疮(SLE)与桥本氏甲状腺炎(HT)合并的临床和实验室特点,指导临床诊治。方法:回顾性分析昆明地区1 029例SLE患者中29例合并HT的临床和实验室特点。结果:1 029例SLE患者中,29例SLE伴发HT(2. 8%); SLE伴发HT时抗SSB和抗RNP抗体阳性率高,0R值分别为6. 43和2. 12;而贫血发生率低,抗SSA阳性率低,0R值分别为0. 73和0. 45。结论:①SLE合并HT占SLE患者的2. 8%,且发病年龄大于SLE单发;②SLE合并HT时血液系统受累减少,抗SSA抗体是二者伴发的保护性因素,而抗RNP和抗SSB抗体是危险因素。

Objective:To study the clinical features of systemic lupus erythematosus (SLE) concurrence with Hashimoto′s thyroiditis (HT) so that the results can be applied to clinical diagnosis and treatment. Methods: The clinical and laboratory characteristics of 29 patients of SLE concurrence with HT in 1 029 patients of SLE in kunming were retrospectively analyzed. Results: The incidence rate of SLE concurrence with HT was 2.8%(29/1 029) in 1 029 SLE cases.The positive rate of anti-SSB and anti-RNP antibody was higher in SLE concurrence with HT than SLE without accompaning with HT,and the OR value was 6.43 and 2.12 respectively.However,the incidence of anemia and the positive rate of anti-SSA were lower than SLE without accompaning with HT,and the OR value was 0.73 and 0.45 respectively. Conclusion:①SLE combined with HT accounted for 2.8% in 1 029 cases with SLE,and the onset age was greater than that of SLE.②When SLE was combined with HT,the blood system involved was reduced,and the anti-SSA antibody was a protective factor,while anti-RNP and anti-SSB antibodies were risk factors.