基于数据挖掘分析《普济方》瘿病用药规律

Discussion on medication rule of treating thyroid disease in Prescriptions for Universal Relief based on data mining

目的:分析《普济方》中所有治疗瘿病方剂的用药特点、组方规律,为瘿病的中医药治疗提供参考。方法:收集《普济方》中所有治疗瘿病的方剂,录入中医传承辅助平台V2.5中,进行用药规律、组方特点分析。结果:对书中记载的96首方剂进行统计分析,得出2个首选药物和11个常用药及其频次,1个首选组合和16个常用组合及其关联规则,6个新核心组合以及3个新方。并且绘制出网络展示图。结论:《普济方》中瘿病的主要病机以气滞痰凝为主,理气化痰散结是治疗瘿病的基本法则,辅以温肾助阳,辨证加入清热利咽等药物。

Objective:To analyze the medication characteristics and formula rule of all prescriptions of treating thyroid disease in Prescriptions for Universal Relief,in order to provide a reference for TCM treatment of thyroid disease. Methods:All prescriptions of treating thyroid disease in Prescriptions for Universal Relief were collected,and input into traditional Chinese medicine inheritance auxiliary platform V2.5.The medication rule and formula characteristics were analyzed. Results:96 initial prescriptions recored in the book were statistically analyzed. The obtained results were as followed:2 preferred drugs,11 commonly using drugs and their frequency;1 preferred combination,16 commonly using combinations and their association rule;6 new core combinations and3 new prescriptions.And a network display diagram was drawn. Conclusion:In Prescriptions for Universal Relief,the main pathogenesis of thyroid disease takes qi stagnation and coagulated phlegm as main;regulating qi to remove phlegm and resovle mass is basic law of treating thyroid disease;warming kidney to strengthen yang as auxiliary;drugs for clear away heat to relieve sore throat etc. are added by syndrome differentiation.