自拟化湿疏肝汤治疗腹泻型肠易激综合征之肝郁脾虚证的疗效观察

Observation of clinical efficacy of self-made Huashi shugan decoction in treating diarrhea-predominant irritable bowel syndrome due to liver-stagnation and spleen-deficiency syndrome

目的 :观察自拟化湿疏肝汤治疗腹泻型肠易激综合征的临床疗效。方法 :收集2016年10月—2018年9月收治的腹泻型肠易激综合征患者90例,随机分为观察组和对照组各45例。观察组给予自拟化湿疏肝汤治疗,每日1剂,分早晚2次服用,每次150 ml;对照组予双歧杆菌三联活菌胶囊420 mg,每日3次,马来酸曲美布汀胶囊200 mg,每日3次,两组均治疗4周。观察两组近、远期临床疗效及症状积分变化。结果 :观察组治疗后及3个月后各积分均较治疗前有显著降低(P <0.01);与对照组相比,治疗后及3个月后的腹痛、大便频次、大便性状、情绪积分有显著降低(P <0.01或P <0.05)。结论 :自拟化湿疏肝汤对腹泻型肠易激综合征的临床疗效优于双歧杆菌三联活菌胶囊+马来酸曲美布汀胶囊。

Objectives: To observe the clinical effect of self-made Huashi shugan decoction in the treatment of diarrheapredominant irritable bowel syndrome. Methods: Ninety patients with diarrhea-predominant irritable bowel syndrome(IBS)admitted from October 2016 to September 2018 were collected and randomly divided into an observation group and a control group with 45 cases in each group. The observation group was treated with self-made Huashi shugan decoction, one dose a day,twice in the morning and evening, 150 ml each time. The control group was given bifidobacterium triple viable capsule 420 mg three times a day, and trimebutine maleate capsule 200 mg 3 times a day. Both groups were treated for 4 weeks. The short-term and long-term clinical effects and the changes of symptom scores were observed in the two groups. Results: All scores in the observation group were significantly lower after treatment and after 3 months of treatment than those before treatment(P<0.01).Compared with the control group, abdominal pain, frequency of stool, stool characteristics and emotional score were significantly decreased after treatment and after 3 months of treatment(P<0.01 or P<0.05). Conclusion: The clinical effect of self-made Hushui shugan decoction on diarrhea-predominant irritable bowel syndrome is better than that of bifidobacterium triple viable capsule +trimebutine maleate capsule.