强的松预防一期梅毒青霉素治疗期间吉海反应的效果

Effect of prednisone on Jihai reaction during primary syphilis with penicillin therapy

目的 探讨强的松预防一期梅毒青霉素治疗期间吉海反应的效果。方法 选择进行青霉素治疗的68例一期梅毒患者为研究对象,按照随机数表法将患者随机分为对照组与观察组,每组34例。对照组患者在青霉素治疗期间不使用药物预防吉海反应,观察组患者在青霉素治疗期间使用强的松预防吉海反应,对比2组患者的吉海反应发生率。结果 观察组患者发生吉海反应表现有高热寒战1例(2.94%)、呼吸加快2例(5.88%)、头疼1例(2.94%);对照组患者发生吉海反应表现有高热寒战4例(11.76%)、呼吸加快3例(8.82%)、头疼2例(5.88%)、恶心呕吐1例(2.94%)。观察组的吉海反应发生率为5.88%,显著低于对照组的17.65%(P<0.05)。结论 使用强的松能有效预防一期梅毒患者青霉素治疗期间的吉海反应。

Objective To explore the effect of prednisone in prevention of Jihai reaction during primary syphilis penicillin treatment. Methods A total of 68 patients with primary syphilis treated with penicillin in our hospital were randomly divided into control group and observation group according to the random number table method, with 34 cases in each group. The control group did not use drugs to prevent Jihai reaction during penicillin treatment, while the observation group used prednisone to prevent Jihai reaction during penicillin treatment. The incidence of Jihai reaction were compared between the two groups. Results There were 1 case of high fever and chills (2.94%), 2 cases of rapid breathing (5.88%) and 1 case of headache (2.94%) in the observation group, and 4 cases of high fever and chills (11.76%), 3 cases of rapid breathing (8.82%), 2 cases of headache ( 5.88%) and 1 case of nausea and vomiting (2.94%) in the control group. The incidence of Jihai reaction in the observation group was significantly lower than that in the control group(5.88%vs. 17.65%, P <0.05). Conclusion Prednisone can effectively prevent the Jihai reaction of patients during the first stage of syphilis penicillin treatment.