肠内营养对无创通气治疗慢性阻塞性肺疾病并发呼吸衰竭患者营养状态及免疫功能的影响

Effect of enteral nutrition on nutritional status and immune function in patients with chronic obstructive pulmonary disease complicated with respiratory failure by non-invasive ventilation

目的 探讨肠内营养在无创通气治疗慢性阻塞性肺疾病(COPD)并发呼吸衰竭患者中的干预效果。 方法 选取60例COPD并发呼吸衰竭患者,分为常规组(鼻饲营养支持)和研究组(肠内营养支持),各30例,干预1个月后观察效果。 结果 研究组并发症发生率显著低于常规组,临床症状消失时间、呼吸功能恢复时间、平均住院时间显著短于常规组(P<0.05);研究组白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)显著低于常规组,血清铁水平、呼气流量峰值(PEF)、第1秒用力呼气容积占预计值百分比(FEV1%)等指标显著高于常规组(P<0.05);干预后,研究组呼吸功能评分及呼吸频率显著低于常规组和干预前(P<0.05)。 结论 肠内营养在无创通气治疗COPD并发呼吸衰竭患者中干预效果显著。

Objective To study the effect of enteral nutrition for patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure by non-invasive ventilation. Methods Sixty patients with COPD complicated with respiratory failure were were divided into conventional group (nasal feeding) and study group (enteral nutrition support), with 30 cases per group. Clinical effect was observed after 1 month of intervention. Results The complication rate of the study group was lower, the time of clinical symptom disappearance, recovery time of respiratory function, and average hospital days were shorter than that of the conventional group( P <0.05). The interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) in the study group was lower, serum iron level, respiratory flow peak (PEF), and ratio of forced vital capacity in the first second to a predicted value(FEV 1%) were higher than that in the conventional group( P <0.05). After intervention, the study group had lower respiratory function score and respiratory rate than before intervention and routine group( P <0.05). Conclusion Enteral nutrition is effective in the treatment of COPD patients complicated with respiratory failure in non-invasive ventilation.