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鼻咽癌CT影像组学量化分析研究 被引量:2

Quantitative analysis of CT radiomics features of nasopharyngeal carcinoma
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摘要 目的:分析不同强化时相鼻咽癌CT影像组学特征的差异及其变化规律。方法:回顾性分析41例初诊鼻咽癌患者CT图像,每组CT图像包含平扫、动脉期、静脉期3个时相,将大体肿瘤靶区(GTV)和翼外肌设置为感兴趣区。比较不同时相GTV、翼外肌间影像组学特征参数的差异。结果:在平扫与动脉期、平扫与静脉期、动脉期与静脉期3组比较中,GTV和翼外肌各自差异有统计学意义的特征分别有18、21、9个和31、31、22个。在动脉期、静脉期与平扫的比较中,GTV灰度强度四分位差随分位数增大而增大。GTV与翼外肌在平扫、动脉期、静脉期的比较中,差异具有统计学意义的特征平扫时主要分布在灰度共生矩阵。3组比较中共有的差异有统计学意义的特征有18个,经接受者操作特性(Receiver Operating Characteristic)曲线分析,有10个特征预测GTV满足ROC曲线下面积≥0.9,全部分布于灰度共生矩阵、灰度强度。结论:CT影像组学可以量化分析鼻咽癌肿瘤与正常组织在多期CT图像中的细微差异,客观反映其动态变化,为鼻咽癌的精确诊断和定量分析提供参考。 Objective To analyze the differences and change patterns of radiomics features in the multi-phase contrast-enhanced computed tomography (CT) images of nasopharyngeal carcinoma (NPC). Methods The CT images of 41 patients with newly diagnosed NPC were retrospectively analyzed. Each group of CT images consisted of 3 phases, namely plain scan, arterial phase and venous phase. The gross tumor volume (GTV) and pterygoid muscle at each phase were set as regions of interest. Finally, the differences in CT radiomic features of GTV and pterygoid muscle were compared among different phases. Results The comparisons of plain scan and arterial phase, plain scan and venous phase, arterial phase and venous phase showed that there were 18, 21, 9 and 31, 31, 22 statistically significant features of GTV and pterygoid muscle, respectively. The comparison among arterial phase, venous phase and plain scan revealed that the interquartile range of intensity direct in GTV was increased with the increase of the quantile. The statistically significant features of GTV and pterygoid muscle which were found in the comparison among plain scan, arterial phase and venous phase were mainly distributed in the gray level co-occurrence matrix. Among them, 18 common features of GTV and pterygoid muscle were analyzed with receiver operating characteristic curve. There were 10 feature predicting that GTV had an AUC≥0.9 (Area Under Curve), and all of these features were distributed in the gray level co-occurrence matrix and intensity direct. Conclusion CT radiomics can quantitatively analyze the subtle discrepancy of NPC and normal tissues in multi-phase CT images, reflect the dynamic variations and provide a reference for the accurate diagnosis and quantitative analysis of NPC.
作者 李腾翔 巩贯忠 仇清涛 尹勇 邱小平 LI Tengxiang;GONG Guanzhong;QIU Qingtao;YIN Yong;QIU Xiaoping(School of Nuclear Science and Technology,University of South China,Hengyang 421001,China;Department of Radiophysical Technology,Shandong Cancer Hospital,Shandong University,Ji'nan 250117,China)
出处 《中国医学物理学杂志》 CSCD 2019年第5期551-555,共5页 Chinese Journal of Medical Physics
基金 国家重点研发计划(2017YFC0113202)
关键词 鼻咽癌 影像组学 量化分析 异质性 nasopharyngeal carcinoma radiomics quantitative analysis heterogeneity
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