低强度脉冲超声的生物物理学效应及相关机制的研究进展

Progress in biophysical effects of low-intensity pulsed ultrasound and related mechanisms

低强度脉冲超声(LIPUS)的能量强度较低(<3 W/cm2)并以脉冲波形式输出,作为一种非侵入性的治疗方法现已逐渐用于临床。LIPUS由于其低强度脉冲输出模式而具有的热效应非常小,主要依靠其非热效应发挥治疗作用。此外,LIPUS相应的分子生物学机制主要包括其相关的信号传导通路、基因表达、血管生成和干细胞分化等。目前,LIPUS的具体机制较复杂,本研究就LIPUS的生物物理学效应及其相关机制作一综述,旨在为LIPUS在更多疾病中的广泛应用提供相应的理论基础和最新的研究进展。

As a non-invasive treatment approach, low-intensity pulsed ultrasound (LIPUS) which has low energy intensity (< 3 W/cm^2) and outputs in pulse waves is gradually used in clinic. LIPUS has an insignificant thermal effect due to its low intensity pulse output mode, and the therapeutic effect of LIPUS mainly depends on its non-thermal effect. The corresponding molecular biological mechanisms of LIPUS mainly include related signal transduction pathways, gene expression, angiogenesis and stem cell differentiation. At present, the specific mechanism of LIPUS is very complex. Herein the biophysical effects and mechanisms of LIPUS are reviewed, so as to provide the corresponding theoretical basis and the latest research progress for the widespread application of LIPUS in more diseases.