止血保胎饮治疗先兆流产的效果及对β-HCG、PRL水平的影响

Study on Effect of Zhixue Baotai Yin on Levels of PRL and β-HCG in Patients with Threatened Abortion

目的:分析止血保胎饮治疗先兆流产对患者绒毛膜促性腺激素(β-HCG)、催乳素(PRL)水平影响情况。方法:先兆流产患者88例,根据治疗方法不同分为对照组和观察组。对照组患者采用黄体酮保胎,观察组患者采用止血保胎饮保胎,分析两组患者治疗后的保胎效果。结果:治疗前,两组患者中医症候积分比较,差异无统计学意义(P>0.05)。治疗后,观察组患者中医症候积分低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者β-HCG、PRL、PIBF、E_2、CA125、炎症因子水平比较,差异无统计学意义(P>0.05)。治疗后,观察组患者β-HCG、PRL、PIBF、E_2、IL-4、IL-10水平高于对照组,CA125、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。观察组患者足月妊娠率高于对照组,早产率低于对照组,流产率与对照组比较,差异无统计学意义(P>0.05)。结论:止血保胎饮治疗先兆流产可缓解临床症状,改善β-HCG、PRL、PIBF水平,抑制炎症反应,提高足月妊娠率。

Objective:To analyze the effect of Zhixue Baotai Yin on the levels of chorionic gonadotropin(β-HCG) and prolactin(PRL) in patients with threatened abortion. Methods:88 patients with threatened abortion were selected and divided into control group and observation group according to different treatment methods. The patients in the control group were treated with progesterone and those in the observation group were treated with Zhixue Baotai Yin. Results:Before treatment, there was no significant difference in TCM symptom scores between the two groups(P>0.05). After treatment, the score of TCM symptom in the observation group was lower than that in the control group(P<0.05). Before treatment, there was no significant difference in the levels of inflammatory factors between the two groups(P>0.05). After treatment, the levels of β-HCGG, PRC,E2,PIBFN,L-4 and IL-10 in the observation group was higher than those in the control group, and the levels of TNF-αin the control group were lower than those in the control group. There was a significant difference in the level of IL-10 between the two groups(P<0.05). The full-term pregnancy rate in the observation group was higher than that in the control group. The premature delivery rate was lower than that in the control group and the abortion rate was not significantly different from that in the control group(P>0.05). Conclusion:Treatment of threatened abortion with Zhixue Baofei Yin can relieve clinical symptoms, improve the levels of PRL and PIBF, inhibit inflammatory reaction and increase the rate of term pregnancy.