如何面对肝素诱导血小板减少症诊断的困惑

Facing the diagnostic challenges of heparin induced thrombocytopenia

肝素诱导血小板减少症(HIT)是应用肝素后不良反应。临床表现为血小板计数减少和高血栓形成风险。因发病隐蔽,临床表现无特异性,未经早期诊断和治疗,致残、致死率高。临床实验室应在HIT早期识别、诊断和治疗上提供重要支持,避免漏诊和过度诊断。

Heparin-induced thrombocytopenia (HIT) is an adverse reaction after exposure to heparin. Clinical manifestations include reduction in platelet count and high risk of thrombosis. HIT often cause high disability and mortality due to the concealed feature, non-specific clinical manifestations, and the delayed diagnosis and treatment. Clinical laboratories should provide important support for early identification, diagnosis, and treatment of HIT to avoid missed diagnosis and over-diagnosis.