血栓前体蛋白对急性心肌梗死与不稳定型心绞痛的早期诊断价值分析

Early Diagnosis Value of Thrombus Precursor Protein in Acute Myocardial Infarction and Unstable Angina Pectoris

目的 探讨血栓前体蛋白对急性心肌梗死与不稳定型心绞痛的早期诊断价值。方法 选取2017年2月—2018年11月收治的研究对象为84例急性冠状动脉综合征患者,按照疾病类型分为两组,即观察1组(急性心肌梗死)--42例,观察2组(不稳定型心绞痛)--42例;同期选择42名健康体检人员作为研究对象--对照组,且对三组受检人员检测后的血栓前体蛋白及磷酸肌酸激酶、同工酶含量进行观察及评估。结果 观察1组血栓前体蛋白(9.72±1.45)mg/L高于观察2组(2.75±0.57)mg/L与对照组(2.87±0.65)mg/L(t=31.13、27.94,P<0.05),而观察2组血栓前体蛋白(2.75±0.57)mg/L与对照组血栓前体蛋白(2.87±0.65)mg/L对比无差异(t=0.89,P=0.01);观察1组磷酸肌酸激酶(598.27±12.52)u/L、观察2组磷酸肌酸激酶(134.52±8.52)u/L均高于对照组(52.65±3.52)u/L(t=271.89、57.56,P<0.05);观察1组同工酶含量(102.52±5.65)u/L高于观察2组(10.05±1.35)u/L与对照组(9.89±1.23)u/L(t=103.64、103.82,P<0.05),而观察2组工酶含量(10.05±1.35)u/L与对照组工酶含量(9.89±1.23)u/L中对比无差异(t=0.57,P=0.57)。结论 对急性心肌梗死与不稳定型心绞痛患者选择检测血栓前体蛋白具有较高的临床价值,有利于尽早区分两者疾病不同,继而为临床治疗提供正确方向。

Objective To investigate the early diagnostic value of thrombus precursor protein in acute myocardial infarction and unstable angina pectoris. Methods A total of 84 patients with acute coronary syndrome were enrolled from February 2017 to November 2018. They were divided into two groups according to the type of disease, ie, observation group 1 (acute myocardial infarction)- 42 cases, observation group 2 (unstable angina)- 42 cases;and 42 healthy subjects were selected as the control group. The thrombus precursor protein and phosphocreatine kinase and isoenzyme content of three groups after detection were observed and evaluated. Results The thrombus precursor protein (9.72±1.45)mg/L in group 1 was higher than that in observation group 2(2.75±0.57)mg/L and control group (2.87±0.65)mg/L(t=31.13, 27.94)P<0.05, and there was no difference between the two groups of thrombus precursor protein (2.75±0.57)mg/L and the control group of thrombus precursor protein(2.87±0.65)mg/L,(t=0.89,P=0.01). Phosphocreatine kinase was (598.27±12.52)U/L in group 1, and (134.52±8.52)U/L in group 2, which were higher than that in the control group (52.65±3.52)U/L,(t=271.89, 57.56, P<0.05). The isozyme content of group 1 was (102.52±5.65)u/L, which was higher than that of observation group 2 (10.05±1.35)U/L and control group (9.89±1.23)U/L(t=103.64, 103.82,,P<0.05). There was no difference of the enzyme content of between group 2 (10.05±1.35)U/L and control group (9.89±1.23)U/L (t=0.57, P=0.57). Conclusion It has high clinical value for the detection of thrombus precursor protein in patients with acute myocardial infarction and unstable angina pectoris. It is helpful to distinguish the two diseases as early as possible, and then provide the correct direction for clinical treatment.