慢性阻塞性肺疾病合并肺动脉高压患者凝血因子与血清炎性因子及血气分析的相关性研究

Correlation between Coagulation Factor and Serum Inflammatory Factor And Blood Gas Analysis In Patients With Chronic Obstructive Pulmonary Disease Complicated With Pulmonary Hypertension

目的 探讨慢性阻塞性肺疾病合并肺动脉高压患者凝血因子与血清炎性因子及血气分析的相关性。方法 选取2015年1月—2017年12月该院收治的慢性阻塞性肺疾病患者120例,根据是否合并肺动脉高压分为观察组(合并肺动脉高压)52例和对照组(未合并肺动脉高压)68例,分别检测两组血浆纤维蛋白原(FIB)、D-二聚体(D-D)和高敏C反应蛋白(hs-CRP)、白介素6(IL-6)及其动脉血氧分压(PaO_2)和二氧化碳分压(PaCO_2),运用直线相关分析凝血因子与血清炎性因子及血气分析的相关性。结果 观察组hs-CRP、 IL-6FIB、D-D明显高于对照组PaO_2明显低于对照组,比较差异有统计学意义(P<0.05);通过直线相关分析发现,FBI和D-D水平与hs-CRP呈正相关(r=0.410、0.315,P<0.05),与IL-6呈正相关(r=0.336、0.307,P<0.05);与PaO_2呈负相关(r=-0.650、-0.549,P<0.05),与PaCO_2呈正相关(r=0.524、0.541,P<0.05)。结论 通过监测患者血浆FBI、D-D含量,血清炎性因子水平和动脉血气分析变化,能够评估慢性阻塞性肺疾病合并肺动脉高压患者血栓发生风险和预后。

Objective To investigate the correlation between coagulation factor and serum inflammatory factor and blood gas analysis and risk factors of hypercoagulability in patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension. Methods A total of 120 patients with chronic obstructive pulmonary disease in our hospital were selected from January 2015 to December 2017. According to whether the pulmonary hypertension was combined, they divided into observation group (n=52, with pulmonary hypertension) and control group (n=68, without pulmonary hypertension). D-Two aggregates (d-d) and sensitive C-reactive proteins (HS-CRP), interleukin 6 (IL-6), arterial oxygen pressure (PaO2) and carbon dioxide compression (PaCO2) were detected. Correlation between clotting factors and serum inflammatory factors and blood gas was analyzed with linear correlation analysis. Results HS-CRP, IL-6, FIB, d-d and PaCO2 in the observation group were significantly higher than those in the control group, and the PaO2 was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). Through linear correlation analysis, it was found that the level of FBI and d-d was positively correlated with HS-CRP (r=0.410, 0.315,P<0.05) and positively correlated with IL-6 (r=0.336, 0.307, P<0.05). It was negatively correlated with PaO2 (r=-0.650,-0.549, P<0.05) and positively correlated with PaCO2 (r=0.524, 0.541, P<0.05). Conclusion It is possible to evaluate the risk and prognosis of thrombosis in patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension by monitoring the changes of plasma FBI, d-d content, serum inflammatory factor level and arterial blood gas analysis.