头部脂溢性皮炎的临床表现与治疗方式分析

Clinical Manifestations and Treatment of Seborrheic Dermatitis of the Head

目的 探讨头部脂溢性皮炎的临床表现与治疗方式。方法 选取2017年1月—2018年9月期间该院收治的74例头部脂溢性皮炎患者,随机分为对照组和观察组,各37例。对照组采用他克莫司乳膏治疗,观察组在对照组基础上增加伊曲康唑胶囊治疗,对比两组患者临床疗效,监测两组患者治疗后不良反应情况,疗程结束后对比两组真菌镜检阴性率,观察两组3个月内复发率。结果 观察组总有效率(94.59%)显著高于对照组(81.08%),差异有统计学意义(χ~2=5.352,P=0.021)。观察组不良反应发生率(5.41%)与对照组比较(2.70%),差异无统计学意义(χ~2=1.826,P=0.518)。观察组真菌镜检阴性率(83.78%)显著高于对照组(67.57%),差异有统计学意义(χ~2=4.726,P=0.021);观察组3个月内复发率(2.63%)显著低于对照组(18.92%),差异有统计学意义(χ~2=5.203,P=0.019)。结论 头部脂溢性皮炎存在多种皮损表现,采用他克莫司乳膏联合伊曲康唑胶囊治疗,抗真菌效果良好,复发率较低。

Objective To investigate the clinical manifestations and treatment of seborrheic dermatitis of the head. Methods A total of 74 patients with seborrheic dermatitis of the head admitted to our hospital from January 2017 to September 2018 were randomly divided into control group and observation group, 37 cases in each group. The control group was treated with tacrolimus cream, while the observation group was treated with itraconazole capsule on the basis of the control group. The clinical efficacy, adverse reactions, negative rate of fungal microscopy and recurrence of the two groups were compared. Results The total effective rate of the observation group (94.59%) was significantly higher than that of the control group (81.08%), the difference was statistically significant (χ^2=5.352,P=0.021). The incidence of adverse reactions in the observation group (5.41%) was not significantly different from that in the control group (2.70%)(χ^2=1.826,P=0.518). The negative rate of fungal microscopy in the observation group (83.78%) was significantly higher than that in the control group (67.57%). The difference was statistically significant (χ^2=4.726,P=0.021). Within three months, the recurrence rate in the observation group (2.63%) was significantly lower than that in the control group (18.92%)(χ^2=5.203,P=0.019). Conclusion There are many skin lesions in seborrheic dermatitis of the head. Tacrolimus cream combined with itraconazole capsule has good antifungal effect, with low recurrence rate.