登革热伴血小板减少的临床分析

Clinical Analysis of Dengue Fever with Thrombocytopenia

目的 探讨登革热合并血小板减少疾病患者的临床特征,以对疾病治疗提供参考依据。方法 选择该院2016年12月—2018年7月收治的128例登革热患者作为实验对象;依据其是否合并血小板减少症状进行分组;A1组(70例):合并表现出血小板减少现象;A2组(58例):未合并表现出血小板减少现象;针对两组患者的疾病特征进行分析对比。结果 对于A1组70例患者,其最高平均体温为(39.41±5.79)℃,对于A2组58例患者,其最高平均体为(38.90±5.99)℃,组间比较,差异无统计学意义(t=0.488 3,P=0.626 1);A1组患者发热持续时间为(4.53±1.05)d,A2组为(2.92±0.85)d,A1组长于A2组明显(t=0.000 0,P=9.399 4);A1组NE水平、WBC水平、AST水平、PLT水平以及LDH水平同A2组之间差异有统计学意义(t=4.362 0, 5.499 7,13.886 3,17.025 5, 13.396 1, P<0.05);A1组LDH、AST以及CK升高,WBC降低同A2组之间差异有统计学意义(χ~2=17.894 4,14.801 2,11.664 1,19.189 5, P<0.05)。结论 对于登革热合并血小板减少患者,于早期较易呈现出组织器官损害以及出血的现象,对此需要给予高度重视,防止病情不断发展后最终呈现出休克综合征以及血热的情况。

Objective To investigate the clinical characteristics of patients with dengue fever combined with thrombocytopenia, so as to provide reference for the treatment of the disease. Methods A total of 128 patients with dengue fever admitted to our hospital from December 2016 to July 2018 were selected as the experimental subjects. They were divided into two groups according to whether they had thrombocytopenia symptoms or not. Group A1 (70 cases) showed thrombocytopenia combined with thrombocytopenia;Group A2 (58 cases) showed no thrombocytopenia combined with thrombocytopenia. And the disease characteristics of the two groups were analyzed and compared. Results For the 70 patients in the A1 group, the highest average body temperature was (39.41±5.79)°C. For the 58 patients in the A2 group, the highest average body was (38.90±5.99)°C. The difference between the groups was not statistically significant (t=0.488 3, P=0.626 1);The duration of fever in group A1 was (4.53±1.05)d,(22.9±0.85)d in group A2, and that in group A1 was longer than that in group A2 (t=0.000 0, P=9.399 4). There was a statistically significant difference in NE level, WBC level, AST level, PLT level and LDH level between A1 group and A2 group (t=4.362 0, 5.499 7 , 13.886 3, 17.025 5, 13.396 1, P<0.05) The LDH, AST, and CK in the A1 group were significantly higher than those in the A2 group (χ^2=17.894 4, 14.801 2, 11.664 1, 19.189 5,P< 0.05). Conclusion For patients with dengue fever combined with thrombocytopenia, it is easy to show tissue and organ damage and hemorrhage in the early stage. Great attention should be paid to prevent shock syndrome and hemorrhagic fever after the disease develops.