摘要
阿德福韦酯和替比夫定均是抗病毒药物,临床上常用于抗乙肝病毒治疗。在慢性乙型肝炎的治疗过程中,阿德福韦酯主要用于对拉米夫定、替比夫定或恩替卡韦耐药的联合治疗中,而替比夫定作为妊娠B级药物,在慢性乙型肝炎的妊娠女性患者治疗中发挥更好的优势。临床研究显示阿德福韦酯容易引起肾功能损伤,而替比夫定可以发挥改善肾功能的作用,且与阿德福韦酯联合使用可以减少阿德福韦酯引起的肾功能受损。本文将两种药物对肾功能的影响进行综述。
Adefovir dipivoxil and telbivudine are antiviral drugs commonly used in the treatment of hepatitis B virus.In the treatment of chronic hepatitis B,Adefovir dipivoxil is mainly used in combination therapy for patients who are resistant to Lamivudine,Telbivudine or Entecavir.Telbivudine,as a grade B drug for pregnancy,plays a better role in the treatment of pregnant women with chronic hepatitis B.Clinical studies have shown that Adefovir Dipivoxil is prone to cause renal impairment,and Telbivudine can improve renal function.Combined with Adefovir Dipivoxil,it can reduce impaired renal function caused by Adefovir Dipivoxil.This article reviews the effects of two drugs on renal function.
作者
赵康路
ZHAO KangLu(The Fourth Affiliated Hospital,Medical School of Zhejiang University,Yiwu 322000,China)
出处
《分子影像学杂志》
2019年第2期238-240,共3页
Journal of Molecular Imaging
关键词
阿德福韦酯
替比夫定
肾功能
adefovir dipivoxil
telbivudine
renal function