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阿德福韦酯和替比夫定对肾功能影响的研究进展 被引量:2

Advances in the effects of adefovir and telbivudine on renal function
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摘要 阿德福韦酯和替比夫定均是抗病毒药物,临床上常用于抗乙肝病毒治疗。在慢性乙型肝炎的治疗过程中,阿德福韦酯主要用于对拉米夫定、替比夫定或恩替卡韦耐药的联合治疗中,而替比夫定作为妊娠B级药物,在慢性乙型肝炎的妊娠女性患者治疗中发挥更好的优势。临床研究显示阿德福韦酯容易引起肾功能损伤,而替比夫定可以发挥改善肾功能的作用,且与阿德福韦酯联合使用可以减少阿德福韦酯引起的肾功能受损。本文将两种药物对肾功能的影响进行综述。 Adefovir dipivoxil and telbivudine are antiviral drugs commonly used in the treatment of hepatitis B virus.In the treatment of chronic hepatitis B,Adefovir dipivoxil is mainly used in combination therapy for patients who are resistant to Lamivudine,Telbivudine or Entecavir.Telbivudine,as a grade B drug for pregnancy,plays a better role in the treatment of pregnant women with chronic hepatitis B.Clinical studies have shown that Adefovir Dipivoxil is prone to cause renal impairment,and Telbivudine can improve renal function.Combined with Adefovir Dipivoxil,it can reduce impaired renal function caused by Adefovir Dipivoxil.This article reviews the effects of two drugs on renal function.
作者 赵康路 ZHAO KangLu(The Fourth Affiliated Hospital,Medical School of Zhejiang University,Yiwu 322000,China)
出处 《分子影像学杂志》 2019年第2期238-240,共3页 Journal of Molecular Imaging
关键词 阿德福韦酯 替比夫定 肾功能 adefovir dipivoxil telbivudine renal function
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  • 1D.Lavanchy.Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures[J]. Journal of Viral Hepatitis . 2004 (2)
  • 2Liaw YF, Chu CM. Hepatitis B virus infection[J]. Lancet, 2009, 373(9663): 582-592.
  • 3Gomes AL, Gouveia A, Capelinha AF, et al. Molecular alterations of KIT and PDGFRA in GISTs: evaluation of a Portuguese series[J]. J Clin Pathol, 2008, 61(2): 203-208.
  • 4Liegl B, Hornick JL, Corless CL, et al. Monoclonal antibody DOGI.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes[J]. Am J Surg Pathol, 2009, 33(3): 437-446.
  • 5Combes B, Shorey J, Barrera A, et al. Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane[J]. Lancet, 1971, 2(7718): 234-237.
  • 6Lai KN, Li PK, Lui SF, et al. Membranous nephropathy related to hepatitis B virus in adults[J]. N Engl J Med, 1991, 324(21): 1457- 1463.
  • 7Appel G. Viral infections and the kidney: HIV, hepatitis B, and hepatitis C[J]. Cleve Clin J Med, 2007, 74(5): 353-360.
  • 8Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Long- term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B[J]. N Engl J Med, 2005, 352(26): 2673-2681.
  • 9James CW, Steinhaus MC, Szabo S, et al. Tenofovir-related nephrotoxicity: case report and review of the literature[J]. Pharrnacotherapy, 2004, 24(3): 415-418.
  • 10Mauss S, Berger F, Schmutz G. Antiretroviral therapy with tenofovir is associated with mild renal dysfunction[J]. AIDS, 2005, 19(1): 93- 95.

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