血清25-(OH)维生素D3与糖尿病周围神经病变相关性研究进展

Advances in the relationship between serum 25-(OH)Vitamin D3 and diabetic peripheral neuropathy

糖尿病最多见的一个并发症为糖尿病周围神经病变(DPN),周围神经功能障碍是其普遍表现,更多表现为下肢的感觉和运动功能异常或障碍,肌肉力量减退,继而发生肌萎缩。国际上关于糖尿病周围神经病变的机制研究有很多,涉及氧化应激、多元醇通路激活、硝基化反应等多个方面。近年来,关于血清25-(OH)维生素D3与DPN相关性的研究越来越多,现对其做一简单综述。

One of the most common complications of diabetes is diabetic peripheral neuropathy(DPN). Patients often have peripheral neurological dysfunction, which features abnormal or impaired sensory and motor function of the extremities, decreased muscle strength, and muscle atrophy. Generally lower extremity lesions are more obvious than upper limbs. There are many studies about the mechanism of diabetic peripheral neuropathy in the world, including oxidative stress, polyol pathway activation, nitration reaction and so on. In recent years, there are more and more studies about the correlation between serum 25-(OH) vitamin D3 and diabetic peripheral neuropathy, so I’ll make a review of these studies.