雾化吸入联合孟鲁司特治疗小儿感染后咳嗽疗效分析

Analysis of curative effect of atomization inhalation combined with montelukast in the treatment of cough after infantile infection

目的探讨雾化吸入联合孟鲁司特治疗小儿感染后咳嗽的临床疗效。方法选择山西大医院儿科2016年1月至2018年1月诊治的感染后咳嗽患儿100例,采用随机数字表法将患儿分为两组,每组50例。对照组不用药,观察组采用孟鲁司特口服+布地奈德雾化吸入治疗,比较两组的临床疗效、症状评分、肺功能指标、炎性因子指标、不良反应。结果观察组总有效率高于对照组[96%(48/50)比80%(40/50),P<0.05]。治疗后,两组的日间咳嗽、夜间咳嗽、咳痰等症状评分均低于治疗前(均P<0.05),而观察组各项症状评分均低于对照组(均P<0.05)。治疗后,观察组1秒用力呼吸容积、1秒用力呼吸容积与肺活量比值这2项肺功能指标均高于对照组(均P<0.05),其C反应蛋白、白细胞介素6、肿瘤坏死因子α等炎性因子指标均低于对照组(均P<0.05)。两组不良反应发生率差异无统计学意义[6%(3/50)比4%(2/50),P>0.05]。结论孟鲁司特口服与布地奈德雾化吸入联合治疗方案可对小儿感染后咳嗽予以有效治疗,可缓解其症状,改善其肺功能,对其呼吸道炎症反应予以抑制,且安全性可靠。

Objective To investigate the clinical efficacy of atomization inhalation combined with montelukast in the treatment of children with post infectious cough. Methods From January 2016 to January 2018, 100 children with post-infection cough were selected and randomly divided into two groups according to the digital table, with 50 cases in each group.The observation group was treated with oral budesonide atomization inhalation.The control group was not given drugs.The clinical efficacy, symptom score, pulmonary function index, inflammatory factor index and adverse reaction were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group[96%(48/50) vs.80%(40/50), P<0.05]. After treatment, the scores of daytime cough, nocturnal cough and expectoration in both two groups were lower than those before treatment(all P<0.05), which in the observation group were lower than those in the control group(all P<0.05). After treatment, the two pulmonary function indicators of FEV1, FEV1/FVC in the observation group were higher than those in the control group(all P<0.05), and the inflammatory cytokines such as CRPIL-6, TNF-α in the observation group were lower than those in the control group(all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups[6%(3/50)比4%(2/50), P>0.05]. Conclusion The combination of oral montelukast and budesonide atomization inhalation can effectively treat children with cough after infection, relieve their symptoms, improve the lung function, suppress the inflammatory reaction of respiratory tract, and it is safe and reliable.