期刊文献+

Caveolin-1、Met蛋白在日光性角化病、鲍温病和皮肤鳞状细胞癌中的表达 被引量:1

Expression of caveolin-1 and Met protein in actinic keratosis, Bowen disease and cutaneous squamous cell carcinoma tissues
下载PDF
导出
摘要 目的:检测Caveolin-1、Met蛋白在肿瘤边缘正常皮肤、日光性角化病、鲍温病和皮肤鳞状细胞癌组织中的表达情况。方法:通过免疫组化SP法,对肿瘤边缘正常皮肤、日光性角化病(Actinic keratosis,AK)、鲍温病(Bowen s Disease,BD)、皮肤鳞状细胞癌(cutaneous squamous cell carcinoma,cSCC)标本中Caveolin-1、Met进行检测。结果:Caveolin-1在正常皮肤、AK、BD、SCC中阳性率依次为16.7%、36.8%、52.9%、78.9%,四组间采用Kruskal-wallis H秩和检验,差异具有统计学意义( P < 0.05 )。Met在正常皮肤、AK、BD、SCC中阳性率依次为8.3%、26.3%、58.8%、84.2%,四组间采用Kruskal-wallis H秩和检验, P <0.05,差异具有统计学意义。在cSCC组中,Caveolin-1、Met阳性表达之间呈现正相关( r=0.484,P =0.036)。结论:Caveolin-1、Met在AK、BD和cSCC细胞中表达强度与恶性程度相关,且Caveolin-1、Met可能在cSCC发生、发展中具有协同作用。 Objective: To detect the expressions of Caveolin-1 and Met in adjacent nonmalignant epithelial tissue, actinic keratosis (AK), Bowen disease (BD) and cutaneous squamous cell carcinoma (cSCC) tissues. Methods: The expressions of Caveolin-1 and Met in normal skin tissues, AK, BD and cSCC were detected by immunohistochemistry SP technique. Results: The positive expression rates of Caveolin-1 in normal skin tissues,AK, BD and cSCC were 16.7%, 36.8%, 52.9% and 78.9% respectively and that of Met were 8.3%, 26.3%, 58.8%, 84.2% respectively, with significant differences among four groups by Kruskal-wallis H Test ( P s<0.05). There was a positive correlation between the level Caveolin-1 and Met expression in cutaneous squamous cell carcinoma ( P <0.05). Conclusion: The positive expression rates of Caveolin-1 and Met in four groups showed a gradual increased trend as the grade malignancy of normal skin, AK, BD and cSCC and there may be a synergism between Caveolin-1 and Met in the development of cSCC.
作者 魏云 吴丽娟 丁高中 冯雨苗 孙澜 WEI Yun;WU Lijuan;DING Gaozhong;FENG Yumiao;SUN Lan(Department of Ultrasound, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou 215001, China)
出处 《中国麻风皮肤病杂志》 2019年第5期276-279,共4页 China Journal of Leprosy and Skin Diseases
关键词 皮肤鳞状细胞癌 日光性角化 鲍温病 CAVEOLIN-1 MET cutaneous squamous cell carcinoma actinic keratosis bowen disease caveolin-1 Met
  • 相关文献

参考文献3

二级参考文献57

  • 1高天文,孙东杰,李春英,何弘,李青,刘友生,刁庆春,黄高升,郝飞,钟白玉,马福成,柳凤轩,闫小初,刘东梅,刘玉峰,刘荣卿.中国西部两医院1905例皮肤恶性肿瘤回顾分析[J].北京大学学报(医学版),2004,36(5):469-472. 被引量:73
  • 2赵天恩,郑家润.皮肤鳞状细胞癌研究进展[J].国际皮肤性病学杂志,2006,32(4):247-250. 被引量:17
  • 3Oyama N, Sekimata M. , Nihei Y, et al. Different growth properties in response to epidermal growth factor and interleukin-6 of primary keratinocytes derived from normal and psoriatic lesional skin [J]. J Dermatol Sci, 1998, 16(2): 120-128.
  • 4Hu YC, Lain KY, Law S, et al. Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cdna arrays. Overexpression of oncogene met correlates with tumor differentiation in ESCC [ J]. Clin Cancer Res, 2001,7(11) : 3519-3525.
  • 5Moriyama T, Kataoka H, Tsubouchi H, et al. Concomitant expression of hepatocyte growth factor (HGF) , HGF activator and c-met genes in human gliomas in vitro [J]. FEBS Lett,1995,372(1) :78-82.
  • 6Uchida D, Kawamata H, Omotehara F, et al. Bole of HGF/c-met system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance [J]. Int J Cancer, 2001,93(4) : 489-496.
  • 7Sawatsubashi M, Sasatomi E, Mizokami H, et al. Expression of c-met in laryngeal carcinoma [J]. Virchows Arch, 1998,432(4) :331.
  • 8Gordinier ME, Steinhoff MM, Hogan JW, et al. S-phase fraction,p53, and HER-2/neu status as predictors of nodal metastasis in early vulvar cancer [J]. Gynecol Oncol. 1997.67(2) : 200 - 202.
  • 9Hove MG, Dinh TV, Hannigan EV, et al. Oncogene expression and microvessel count in recurrent and nonrecurrent stage Ib squamous cell carcinoma of the cervix [ J ]. J Reprod Med, 1999, 44(6) : 493 - 496.
  • 10Jasmin J F, Frank P G, Lisanti M P.Caveolins and caveolae: roles in signaling and disease mechanisms[M].New York: Springer, 2012: 381.

共引文献31

同被引文献4

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部