埃巴病毒潜伏膜蛋白的研究进展

Research Progress of Latent Membrane Protein Encoded by EBV

埃巴病毒(Epstein-Barr Virus, EBV)是一种在人群中感染率高达90%的γ-疱疹病毒,其感染宿主细胞后常以潜伏形式存在并伴随终生,在一定条件诱导下,由潜伏感染转化为裂解感染,导致多种恶性肿瘤的发生。LMP1和LMP2是EBV编码的重要潜伏膜蛋白,它们锚定于细胞膜脂筏区,通过与宿主细胞内多种信号传递分子如TRAF家族蛋白、Caspase家族蛋白和STAT家族等相互作用,参与细胞内多条信号转导通路,进而影响细胞迁移与凋亡,与淋巴组织增生性疾病和恶性肿瘤的发生有着密切联系。本文阐述了LMP1和LMP2的结构特征,在宿主细胞内的基因表达调控及参与信号转导途径的机制等,旨在推进EBV发病机理研究及疫苗的研发等科研进展。

Epstein-Barr virus(EBV) is a human γ-herpes virus which has an infection rate up to 90% in population. After infecting the host cells, EBV stays latent in the cells for life-long period. Under certain inducement, it will transforms from latent infection into lytic infection, which may trigger genesis of several types of malignant tumors. LMP1 and LMP2, the two key latent membrane proteins encoded by EBV, are anchored in the lipid raft region of the host cell membrane, interacting with signaling molecules, such as families of TRAF, Caspase and STAT. LMP1 and LMP2, involved in many signaling pathways, are considered closely related to lymphoproliferative diseases and tumorigenesis through cell migration and apoptosis. This article summarizes and discusses the structure/function of LMP1 and LMP2, focusing on their roles of gene expression regulation and signal transduction pathways in host cells, aiming to pave road for EBV pathogenesis research and related vaccine R&D.