扩大标准供体与标准供体肾移植术后早期肾功能比较

Comparison of early renal function between expanded and standard criteria donor after transplantation

目的比较公民逝世后器官捐献供体(DD)中标准供体(SCD)与扩大标准供体(ECD)供肾移植术后早期肾功能变化情况。方法回顾性分析2017年1—6月在郑州大学第一附属医院肾移植科完成的128例DD供肾肾移植,其中SCD组104例,ECD组24例,两组供肾均行移植前病理穿刺活检,比较两组受体术后6个月内移植肾功能延迟恢复(DGF)发生率及3个月、6个月时血肌酐(Scr)和估算的肾小球滤过率(eGFR)的变化情况。结果ECD组24例供肾移植术后DGF发生率为29.17%(7/24),SCD组104例供肾移植术后DGF发生率为10.58%(11/104),差异有统计学意义(P<0.05)。ECD组术后3个月、6个月时的血肌酐值、eGFR值与SCD组比较,差异无统计学意义(均P>0.05)。结论ECD供肾受者术后早期肾功能仍可以获得较好的效果,可以作为供肾的有效来源。

Objective To compare the changes of early renal function between standard criteria donor (SCD) and extended criteria donor (ECD ) in deceased donor (DD). Methods One hundred and twenty-eight cases of DD kidney transplantation completed in the First Affiliated Hospital of Zhengzhou University from January 2017 to June 2017 were analyzed retrospectively. There were 104 cases in SCD group and 24 cases in ECD group. Pre-transplantation biopsy was performed in both groups. The incidence of delayed graft function within 6 months after operation, the changes of serum creatinine (Scr) and estimated glomerular filtration rate (eGFR) at 3 months and 6 months after operation were compared between the two groups. Results The incidence of DGF was 29.17%(7/24) in ECD group and 10.58%(11/104) in SCD group, there was significant difference between the two groups ( P < 0.05). There was no significant difference in serum creatinine and eGFR between ECD group and SCD group at 3 months and 6 months after operation(all P > 0.05). Conclusion Early postoperative renal function of ECD recipients can still obtain good results and ECD can be used as an effective source of donor.