恶性肿瘤代谢特点及其与炎性介质的相关性研究进展

Advances in Metabolic Characteristics of Malignant Tumors and Their Correlation with Inflammatory Mediators

恶性肿瘤是一种高能量代谢疾病,因其本身的作用,人体对恶性肿瘤的应激反应以及抗癌治疗过程中的措施导致肿瘤患者的代谢特点具有特殊性,如脂肪分解、脂肪酸氧化增加、瘦组织群减少、胰岛素抵抗以及蛋白质代谢紊乱等。而大量代谢产物如脂多糖(LPS)、乳酸、花生四烯酸代谢物(PGE2)、游离脂肪酸(FFA)等常诱发慢性轻度炎症。而很多肿瘤多发生在感染、慢性刺激和炎性反应的部位,所以炎性微环境对肿瘤的影响已成为科研领域的研究重点。而在肿瘤机体代谢的过程中,许多炎性介质参与其中,故本文就肿瘤能量代谢特点、代谢异常与相关炎性介质的关系作一系统总结。

Malignant tumor is are a kind of high-energy metabolic disease. Due to the role of malignant tumors themselves, the human body’s stress response to malignant tumors and the measures in the anti-cancer treatment process lead to the special characteristics of cancer patients, such as lipolysis and increased fatty acids oxidation, decreased lean tissue group, insulin resistance, and protein metabolism disorders etc. A large number of metabolites, such as lipopolysaccharide(LPS), lactic acid, arachidonic acid metabolite(PGE2),free fatty acid(FFA), etc., often induce chronic low-grade inflammation. Many tumors occur in the areas of infection, chronic irritation and inflammation, so the influence of the inflammatory microenvironment on tumors has become the focus in the field of scientific research. In the process of tumor body metabolism,many inflammatory mediators are involved, so this paper summarizes the relationship between tumor energy metabolism characteristics, tumor metabolic abnormalities and related inflammatory mediators.