大容量高速逆流色谱仪分离柱结构设计与优化

Structure design and optimization of large-capacity high-speed countercurrent chromatography separation column

为得到高效、快速、制备量大的分离效果,设计一种大容量高速逆流色谱仪分离柱结构。并使用 ANSYSWorkbench 建立有限元模型,进行静力学分析及模态分析,验证设计的合理性及实用性;再利用响应曲面优化算法,选定分离柱的 3 个关键尺寸作为设计变量,最大等效应力、最大总变形量和模型质量作为优化目标,对优化目标设置条件约束,经过计算得到较为合理的分离柱结构,最后进行疲劳分析校准。整个分析过程可确保该结构设计的可靠性,为后续进行高速逆流色谱仪整机的结构与优化设计提供参考。

In order to obtain high-efficiency, rapid and large-volume separation effect, a large-capacity highspeed countercurrent chromatography separation column scheme was designed. The ANSYS Workbench is used to build the finite element model, and the static analysis and modal analysis are carried out to verify the rationality and practicability of the design. Using the response surface optimization tool, the three key dimensions of the separation column are selected as the design variables. The equivalent stress maximum, the total deformation maximum and the model quality are used as the optimization targets. The condition constraints are set on the optimization targets. After calculation, a more reasonable separation column structure is obtained, and then the fatigue analysis is performed calibration. The whole analysis process ensures the reliability of the structural design, which provides a reference for the subsequent structure and optimization design of the high-speed countercurrent chromatography.