美洲大蠊提取物对心梗后心衰患者的疗效分析

Therapeutic effect of the extract of periplaneta Americana on heart failure patients after myocardial infarction

目的探讨美洲大蠊提取物对心肌梗死后心力衰竭患者的疗效分析,同时观察其对基质蛋白酶抑制剂-4(基质金属蛋白酶抑制剂-4)的影响。方法选取确诊为急性心肌梗死,行PCI术后发生心力衰竭的患者100例,分为治疗组(在常规治疗的基础上应用美洲大蠊提取物治疗)50例和对照组(应用常规药物治疗)50例,治疗10d后,观察两组患者基质金属蛋白酶抑制剂-4,生化指标(甘油三酯、胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇),心脏功能(NT-probnp),舒张末期内径(LVIDd),射血分数(EF),治疗前后的改变,并进行统计学分析。结果治疗后,两组基质金属蛋白酶抑制剂-4均降低,但治疗组基质金属蛋白酶抑制剂-4降低较对照组相比有统计学意义(P<0.05);两组患者治疗后甘油三酯、胆固醇和高密度脂蛋白胆固醇及NT-probnp较治疗前差异均有统计学意义(P<0.05),治疗后治疗组较对照组比较,差异具有统计学意义(P<0.05);两组患者治疗后心脏彩超较治疗前有改善,但差异不显著(P>0.05)。且治疗组较对照组相比有效率较高。结论美洲大蠊提取对心梗后心衰治疗有效,可改善生化指标,短期治疗但对心脏结构改善不明显。

Objective To investigate the effect of Periplaneta americana extract on heart failure patients after myocardial infarction, and to observe its effect on matrixin inhibitor-4(matrix metalloproteinase inhibitor-4). Methods 100 patients with acute myocardial infarction diagnosed with heart failure after PCI were selected and divided into two groups, 50 patients in the treatment group (using the American cockroach extract on the basis of conventional treatment) and 50 patients in the control group (using conventional drug therapy). After 10 days of treatment, the matrix metalloproteinase inhibitor-4, biochemical indicators(triglyceride, cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol) and cardiac function [NT-probnp, LVIDd, and ejection fraction (EF)] were observed in the two groups. Results After treatment, the matrix metalloproteinase inhibitor-4 was decreased in both groups, but the decrease of matrix metalloproteinase inhibitor-4 in the treatment group was statistically significant when compared with that of the control group(P<0.05).After treatment, the triglyceride, cholesterol, high-density lipoprotein cholesterol and NT-probnp in both groups were significantly different with those before treatment(P<0.05), and were significantly different between two groups after treatment(P<0.05). Cardiac color Doppler ultrasound improved after treatment in both groups, but it was not significant(P>0.05). The treatment group was more effective than the control group. Conclusion The extraction of American cockroaches is effective in the treatment of heart failure after myocardial infarction, which can improve biochemical indicators, but the short-term treatment does not improve the cardiac structure.