促红细胞生成素联合神经节苷脂治疗新生儿缺氧缺血性脑病的疗效

The effect of erythropoietin combined with ganglioside in treatment of neonatal hypoxic ischemic encephalopathy

目的观察促红细胞生成素联合神经节苷脂治疗新生儿缺氧缺血性脑病的疗效。方法选择我院2017年1月~2018年1月纳入的60例新生儿缺氧缺血性脑病患儿为研究对象,将全部患儿随机分为观察组和对照组,每组30例,观察组采取促红细胞生成素联合神经节苷脂治疗,对照组采取神经节苷脂治疗,治疗后比较两组的疗效、两组行为神经评分(NBNA)。结果观察组治疗后的总有效率为96.7%,显著高于对照组的70.0%,两组比较,差异有统计学意义(P<0.05)。对两组患儿的NBNA评分进行比较,结果显示,观察组NBNA评分≥35分为正常的比率达80.0%,显著高于对照组,两组比较,差异有统计学意义(P<0.05)。结论促红细胞生成素联合神经节苷脂治疗新生儿缺氧缺血性脑病临床效果显著,可有效减轻神经细胞损害,促进受损神经细胞功能恢复。

Objective To observe the efficacy of erythropoietin combined with ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy. Methods Sixty children with neonatal hypoxic ischemic encephalopathy in our hospital from January 2017 to January 2018 were enrolled. All the children were randomly divided into observation group and control group, with 30 cases in each group. The observation group was treated with erythropoietin and ganglioside. The control group was treated with ganglioside. After treatment, the efficacy and the behavioral neurological score (NBNA) of the two groups were compared. Results The total effective rate of the observation group was 96.7% after treatment, which was significantly higher than that of the control group(70.0%). The difference of clinical efficacy between the two groups was significant(P<0.05). The NBNA scores of the two groups were compared. The results showed that the rate of NBNA score ≥35 points as normalization was 80.0%, which was significantly higher than that in the control group. The difference between the two groups was significant(P<0.05). Conclusion The erythropoietin combined with ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy has significant effect, which can effectively reduce the damage of nerve cells, promote the recovery of damaged nerve cells, improve their physical development and mental development, and improve the prognosis.