氯吡格雷联合辛伐他汀治疗不稳定型心绞痛的临床效果分析

Clinical analysis of clopidogrel combined with simvastatin in the treatment of unstable angina pectoris

目的探讨氯吡格雷联合辛伐他汀治疗不稳定型心绞痛的临床效果。方法选择2017年8月~2018年8月住院收治的80例不稳定型心绞痛患者,随机分为对照组与观察组,各40例,两组均予常规对症治疗,对照组予氯吡格雷治疗,观察组同时联合辛伐他汀进行治疗,治疗后对比分析两组的临床疗效及心电图ST-T段改善情况、两组心绞痛发作情况。结果观察组患者治疗后的临床总有效率为97.50%,对照组为72.50%,两组临床疗效比较,差异具有统计学意义(P<0.05);观察组患者心电图ST-T段改善情况治疗后的总有效率为97.50%,对照组为75.00%,两组心电图ST-T段改善情况比较,差异具有统计学意义(P<0.05);治疗前,两组患者的心绞痛发作频率及心绞痛发作持续时间对比差异不具统计学意义(P>0.05);治疗后,观察组的心绞痛发作频率显著减少,心绞痛发作持续时间显著缩短,与对照组比较,两组存在显著性差异(P<0.05)。结论氯吡格雷联合辛伐他汀治疗不稳定型心绞痛疗效确切,心电图ST-T段改善疗效显著,且心绞痛发作频率明显减少,心绞痛发作持续时间显著缩短,患者恢复较好,值得临床推广和应用。

Objective To analyze the clinical effect of clopidogrel combined with simvastatin in the treatment of unstable angina pectoris. Methods Eighty patients with unstable angina admitted in the hospital from August 2017 to August 2018 were randomly divided into the control group and the observation group, with 40 patients in each group. The two groups were treated with conventional symptomatic treatment. The control group was treated with clopidogrel, and the observation group was treated with clopidogrel and simvastatin. After treatment,the clinical efficacy and improvement of ECG ST-T segment and angina pectoris between two groups were compared. Results The total effective rate of the patients in the observation group was 97.50% after treatment and 72.50% in the control group. There was statistically significant difference in clinical efficacy of the two groups(P<0.05). The total effective rate of ECG ST-T segment improvement was 97.50% in the observation group and 75.00% in the control group. The improvement of ST-T segment between the two groups was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in the frequency of angina pectoris and angina pectoris duration in the two groups(P>0.05). After treatment, the frequency of angina pectoris was significantly reduced in the observation group, and the duration of angina pectoris was significantly shortened. There was a significant difference between the two groups(P<0.05). Conclusion Clopidogrel combined with simvastatin is effective in the treatment of unstable angina pectoris. ECG ST-T segment improved significantly, and the frequency of angina pectoris is significantly reduced. The duration of angina pectoris is significantly shortened. The patient recovers well. The treatment of clopidogrel combined with simvastatin is worthy of clinical promotion and application.