右美托咪定不同给药时间在妇科腹腔镜手术中的效果

The Effect of Dexmedetomidine on Different Administration Time in Gynecological Laparoscopic Surgery

目的探讨分析右美托咪定不同方式给药在妇科腹腔镜手术中的临床应用。方法选取2016年4月—2017年10月我院妇科收治的90例腹腔镜手术患者作为研究对象。采用随机数字表法,将其分为两组。对照组采用术中持续给予右美托咪定泵注,观察组进行在术前15分钟给予右美托咪定快速静脉滴注。比较两组患者的麻醉效果;恶心呕吐、苏醒期高血压、苏醒期躁动、术后寒颤等的发生率;麻醉前后患者心率指标以及平均动脉压指标。术后苏醒时间。结果观察组患者的麻醉总有效率高于对照组,差异具有统计学意义(P <0.05);观察组患者的恶心呕吐、苏醒期高血压、苏醒期躁动、术后寒颤等的发生率低于对照组,差异具有统计学意义(P <0.05);麻醉前,两组心率指标以及平均动脉压指标比较,差异无统计学意义(P> 0.05);麻醉后,观察组患者的心率指标以及平均动脉压指标优于对照组,差异具有统计学意义(P <0.05)。观察组术后苏醒时间短于对照组,差异具有统计学意义(P <0.05)。结论在术前15分钟给予右美托咪定快速静脉滴注在妇科腹腔镜手术麻醉中的效果确切,可更好维持血流动力学稳定,减少不良反应。

Objective To investigate the clinical application of different dexmedetomidine administration in gynecological laparoscopic surgery. Methods From April 2016 to October 2017, 90 cases of laparoscopic surgery in gynecology department of our hospital were selected as the research objects. Random number table method was used to divide it into two groups. The control group was given dexmedetomidine pump continuously during the operation. The observation group received rapid intravenous drip of dexmedetomidine 15 minutes before operation. The anesthesia effect, incidence of nausea and vomiting, hypertension during recovery, restlessness during recovery and post-operative shivering were compared between the two groups. Heart rate and mean arterial pressure before and after anesthesia. Results The total effective rate of anesthesia in the observation group was higher than that in the control group(P<0.05). The incidence of nausea and vomiting, hypertension during recovery, restlessness during recovery and shivering after operation in the observation group was lower than that in the control group, and the difference was statistically significant(P<0.05). Before anesthesia, there was no significant difference in heart rate and mean arterial pressure between the two groups(P>0.05). After anesthesia, the heart rate and mean arterial pressure in the observation group were better than those in the control group, with statistical significance(P<0.05). The recovery time of the observation group was shorter than that of the control group(P<0.05). Conclusion The rapid intravenous infusion of dexmedetomidine 15 minutes before surgery is effective in gynecological laparoscopic anesthesia, which can better maintain hemodynamic stability and reduce adverse reactions.