急性重症胰腺炎早期连续性肾替代治疗效果评价

Evaluation of Early Continuous Renal Replacement Therapy for Acute Severe Pancreatitis

目的分析急性重症胰腺炎早期连续性肾替代治疗(continuous renal replacement therapy,CRRT)治疗效果。方法选取2015年9月—2018年5月我院收治的80例急性重症胰腺炎患者作为研究对象。采用数字随机法,将患者分成两组。对照组采用常规综合治疗,观察组采用早期CRRT治疗,比较两组患者的治疗效果。结果观察组的治疗有效率为90%(36例),对照组的治疗有效率为70%(28例),两组数据比较,差异具有统计学意义(P <0.05),两组死亡率比较,差异不具有统计学意义(P> 0.05);观察组治疗后AMS为(161±14)U/L,IL-1β为(6.3±2.5)ng/L,TNF-α为(45.9±5.3)ng/L,各项数据与对照组比较,差异具有统计学意义(P <0.05)。结论急性重症胰腺炎患早期进行CRRT治疗效果明显,可有效改善患者临床指标。

Objective To analyze the effect of early(continuous renal replacement therapy, CRRT) in acute severe pancreatitis. Methods 88 patients with severe acute pancreatitis admitted to our hospital from September 2015 to May 2018 were selected as the study subjects. The patients were divided into two groups by digital random method. The control group was treated with routine comprehensive treatment. The observation group was treated with early CRRT. The therapeutic effects of the two groups were compared. Results The effective rate of the observation group was 90%(36 cases) and that of the control group was 70%(28 cases). The difference between the two groups was statistically significant(P<0.05). There was no significant difference in mortality between the two groups(P>0.05). The AMS, IL-1β, TNFalpha and TNF-α in the observation group were(161±14) U/L,(6.3±2.5) ng/L and(45.9±5.3) ng/L respectively after treatment. There were significant differences between the data and the control group(P<0.05). Conclusion Acute severe pancreatitis is effective in the early stage of CRRT treatment, which can effectively improve the clinical indicators of patients.