激素联合环磷酰胺冲击治疗肾病综合征的效果

The Effect of Hormone Combined With Cyclophosphamide Pulse Therapy on Nephrotic Syndrome

目的对难治性肾病综合征中的激素与环磷酰胺冲击联合治疗效果进行分析。方法选取本院2013年6月—2015年6月收治的100例难治性肾病综合征患者作为研究对象。根据治疗方法不同,将其分为对照组与治疗组。对照组50例,采用糖皮质激素治疗,治疗组50例,在对照组基础上,进行环磷酰胺冲击治疗。对两组治疗效果及转归情况进行对比分析。结果对照组治疗总有效率低于治疗组,组间比较,差异具有统计学意义(P <0.05)。对照组痊愈率低于治疗组,疾病复发与死亡率超过治疗组,组间比较,差异具有统计学意义(P <0.05);对照组转归情况明显不如治疗组。结论在难治性肾病综合征治疗组,激素与环磷酰胺冲击联合治疗效果比较显著,且转归情况较好,具有临床应用价值。

Objective To analyze the therapeutic effect of hormone and cyclophosphamide in refractory nephrotic syndrome. Methods A total of 100 patients with refractory nephrotic syndrome admitted to our hospital from June 2013 to June 2015 were selected as the study subjects. According to different treatment methods, they were divided into control group and treatment group. 50 cases in the control group were treated with glucocorticoid. 50 cases in the treatment group were treated with cyclophosphamide pulse therapy on the basis of the control group. The therapeutic effect and prognosis of the two groups were compared and analyzed. Results The total effective rate of the control group was significantly lower than that of the treatment group, and there was statistical significance between the two groups(P<0.05). The cure rate of the control group was lower than that of the treatment group, and the disease recurrence and mortality rate were higher than that of the treatment group. There was statistical significance between the two groups(P<0.05). The prognosis of the control group was significantly worse than that of the treatment group. Conclusion In the treatment group of refractory nephrotic syndrome, the combined therapy of hormone and cyclophosphamide shock is more effective, and the prognosis is better, so it has clinical application value.