房颤发生、发展中hs-CRP、TRX、SOD的变化情况

Study the Pathogenesis of High-sensitivity C-reactive Protein,Thioredoxin and Superoxide Dismutase in Atrial Fibrillation Patients

目的探究房颤发生、发展中超氧化物歧化酶(SOD)、硫氧还蛋白(TRX)、高敏C反应蛋白(hs-CRP)量的变化和房颤的发病机制。方法选择2017年5月—2018年4月本院就诊100例房颤者,按房颤发作持续时间分组,分为持续组(n=54)、阵发组(n=46),同时取50例体检健康者为对照组,检查各组SOD、TRX、hs-CRP表达及左心室内径(LVID)情况,比较各组指标表达、LVID值差异。结果持续组LVID、TRX、hs-CRP高于其他两组,SOD水平低于其他两组,差异有统计学意义(P <0.05);阵发组LVID、TRX、hs-CRP指标高于对照组,SOD水平低于对照组,差异有统计学意义(P <0.05)。结论氧化应激及炎性反应在房颤患者左心房的结构重构发病、进展中起到关键性作用。

Objective To study the pathogenesis of high-sensitivity C-reactive protein (hs-CRP), thioredoxin (TRX) and superoxide dismutase (SOD) in atrial fibrillation patients. Methods 100 atrial fibrillation patients from May 2017 to April 2018 were assigned to persistent group (n =54) and paroxysmal group (n =46). 50 healthy check-ups were selected as control group. The SOD, TRX and hs-CRP contents as well as left ventricular diameter (LVID) were evaluated. Results Compared with the other two groups, the values of LVID, TRX and hs-CRP in persistent group were higher and SOD contents were lower (P < 0.05);compared with control group, the values of LVID, and TRX and hs-CRP in paroxysmal group were higher and SOD contents were lower (P < 0.05). Conclusion The oxidative stress and inflammatory response play a key role in the genesis and development of left ventricular remodeling.