麦角新碱联合卡贝缩宫素预防产后出血的效果

Effect of Ergometrine Combined With Carbetocin on Prevention of Postpartum Hemorrhage

目的探讨麦角新碱联合卡贝缩宫素预防剖宫产术后产后出血的效果。方法对2015年2月—2018年5月收治的择期剖宫产孕妇102例进行回顾性分析,根据胎儿娩出后用药情况分组,对照组51例单用缩宫素,观察组51例在对照组基础上给予麦角新碱联合卡贝缩宫素,对两组手术产后出血量、产后出血发生率、输血率、临床疗效及不良反应发生率进行观察。结果观察组产后2 h和产后24 h出血量均较对照组少,产后出血发生率及输血率较对照组低(P <0.05);观察组患者总有效率98.04%,较对照组80.39%高(P <0.05),观察组不良反应发生率7.84%,与对照组5.88%比较差异无统计学意义(P>0.05)。结论麦角新碱联合卡贝缩宫素可有效预防剖宫产后产后出血。

Objective To investigate the effect of ergometrine combined with carbetocin on postpartum hemorrhage after cesarean section. Methods A retrospective analysis was made on 102 pregnant women who received elective cesarean section from February 2015 to May 2018. 51 cases in the control group were treated with oxytocin alone, and 51 cases in the observation group were treated with ergonovine combined with carbetocin on the basis of the control group. The amount of postpartum hemorrhage, incidence of postpartum hemorrhage, transfusion rate, clinical efficacy and incidence of adverse reactions of the two groups were observed. Results The bleeding volume of the observation group at 2 h and 24 h after delivery was lower than that of the control group. The incidence of postpartum hemorrhage was 3.92%, and the transfusion rate was 1.96%, which was lower than that of the control group 15.69% and 13.73%(P < 0.05). The total effective rate of the observation group was 98.04%, which was significantly higher than that of the control group 80.39%(P < 0.05). The incidence of adverse reactions in the observation group was 7.84%, which was not significantly different from the control group 5.88%(P > 0.05). Conclusion Ergometrine combined with carbetocin can effectively prevent postpartum hemorrhage after cesarean section.