经直肠超声检查联合血清CYFRA21-1水平检测在直肠癌患者术前诊断中的应用

Application Value of Transrectal Ultrasonography combined with Serum CYFRA21-1 Level in Preoperative Diagnosis of Rectal Cancer Patients

目的:探讨经直肠超声检查联合血清C角蛋白19片段抗原21-1(CYFRA21-1)水平检测在直肠癌患者术前诊断中的应用。方法:选取我院2016年11月至2018年10月直肠癌患者91例设为研究组,另选取同期健康体检者91例设为对照组,所有患者均接受经直肠超声检查及血清CYFRA21-1水平检测。统计分析研究组与对照组血流动力学参数[舒张末期流速(EDV)、搏动指数(PI)、阻力指数(RI)]及血清CYFRA21-1水平,分析经直肠超声对直肠癌临床分期诊断准确率,比较经直肠超声与血清CYFRA21-1检测对直肠癌单独与联合诊断效能。结果:研究组EDV及血清CYFRA21-1水平高于对照组,RI及PI低于对照组(P<0.05);经直肠超声对直肠癌T分期诊断准确率为89.01%(81/91);联合诊断敏感度(97.80%)、准确度(96.70%)高于经直肠超声(86.81%、92.31%)与血清CYFRA21-1(69.23%、82.42%)单独诊断(P<0.05)。结论:经直肠超声检查联合血清CYFRA21-1水平检测可有效提高直肠癌诊断敏感度与准确度,并能准确评估疾病分期,进而为临床制定、调整治疗方案提供可靠依据。

Objective: To investigate the value of transrectal ultrasonography combined with serum C-keratin 19 fragment antigen 21-1 (CYFRA21-1) level in preoperative diagnosis of rectal cancer patients. Methods: A total of 91 patients with rectal cancer from November 2016 to October 2018 were enrolled in the study group. 91 healthy controls were selected as the control group. All patients underwent transrectal ultrasonography and serum CYFRA21-1 levels. The hemodynamic parameters [End-diastolic velocity (EDV), pulsatility index (PI), resistance index (RI)] and serum CYFRA21-1 levels in the clinical stage of the study group and the control group and the study group were statistically analyzed. The hemodynamic parameters of the study group and the control group [end diastolic flow rate (EDV), pulsatility index (PI), resistance index (RI)] and serum CYFRA21-1 level, analysis of accurate clinical diagnosis of rectal cancer by rectal ultrasound were compared between transrectal ultrasound and serum CYFRA21-1 for the diagnosis of rectal cancer alone and in combination. Results: The EDV and serum CYFRA21-1 levels in the study group were higher than those in the control group, and the RI and PI were lower than the control group (P<0.05). The accuracy of T-stage diagnosis of rectal cancer by rectal ultrasound was 89.01%(81/91);Degree (97.80%) and accuracy (96.70%) were higher than those of transrectal ultrasound (86.81%, 92.31%) and serum CYFRA21-1 (69.23%, 82.42%)(P<0.05). Conclusion: Transrectal ultrasonography combined with serum CYFRA21-1 level detection can effectively improve the sensitivity and accuracy of rectal cancer diagnosis, and can accurately assess the disease stage, and provide a reliable basis for clinical development and adjustment of treatment options.