腹膜前间隙无张力修补对疝气患者血清IL-17与IL-6及IL-8因子水平的影响

Effect of tension-free repair of anterior peritoneal space on serum IL-17,IL-6 and IL-8 factor levels in patients with hernia

目的探讨腹膜前间隙无张力修补在改善疝气患者血清炎症因子中的应用效果。方法 选择2017年3月至2018年9月本院收治的疝气患者110例,使用随机数表法将所有患者分为两组,各55例。对照组予以无张力疝修补术治疗,观察组实施腹膜前间隙无张力修补治疗,比较两组患者血清炎症因子水平、手术相关指标及术后并发症发生情况。结果 术后,观察组IL-6、IL-8、IL-17水平分别为(9.07±1.08)pg/ml、(23.49±7.58)pg/ml、(44.29±11.68)pg/ml,均低于对照组(12.54±1.73)pg/ml、(58.72±11.95)pg/ml、(52.96±13.37)pg/ml,差异均有统计学意义(均P<0.05);观察组术中出血量、手术时间、术后下床活动时间、伤口持续疼痛时间及住院时间分别为(26.94±6.15)ml、(35.72±6.19)min、(2.79±0.86)h、(1.31±0.48)d、(5.06±0.83)d,均少于对照组(45.23±8.07)ml、(41.86±7.29)min、(6.68±1.45)h、(1.72±0.64)d、(8.45±1.29)d,差异均有统计学意义(均P<0.05);观察组术后并发症发生率为3.64%(2/55),低于对照组20.00%(11/55),差异有统计学意义(P<0.05)。结论 腹膜前间隙无张力修补能够在降低疝气患者机体炎症反应及术后并发症发生率的同时,有效缩短术后下床活动时间及疼痛持续时间等,临床疗效确切。

Objective To investigate the effect of tension-free repair of anterior peritoneal space on the improvement of serum inflammatory factors in hernia patients. Methods 110 patients with hernia were selected from March 2017 to September 2018, and were randomly divided into a control group and an observation group, 55 cases for each group. The control group were treated with tension-free hernioplasty, and the observation group with tensionfree repair of anterior peritoneal space. The serum levels of inflammatory factors, surgical parameters, and postoperative complications were compared between the two groups. Results The levels of IL-6, IL-8, and IL-17 as well as the intraoperative bleeding volume, operation time, time for off-bed activity after operation, wound pain duration, and hospitalization time were better in the observation group than in the control group [(9.07±1.08) pg/ml vs.(12.54 ±1.73) pg/ml,(23.49 ±7.58) pg/ml vs.(58.72 ±11.95) pg/ml,(44.29 ±11.68) pg/ml vs.(52.96 ±13.37) pg/ml,(26.94 ±6.15) ml vs.(45.23 ±8.07) ml,(35.72±6.19) min vs.(41.86±7.29) min,(2.79±0.86) h vs.(6.68 ±1.45) h,(1.31±0.48) d vs.(1.72±0.64) d,(5.06±0.83) d vs.(8.45±1.29) d, all P < 0.05]. The incidence of postoperative complications was significantly lower in the observation group than in the control group [3.64%(2/55) vs.(20.00%)(11/55), P < 0.05]. Conclusion Tension free repair of anterior peritoneal space for hernia patients can reduce inflammation reaction, the incidence of postoperative complications, time for off-bed activity after operation, and pain duration, and is effective.