阿托伐他汀联合缬沙坦治疗慢性肾炎患者的临床有效率分析

Atorvastatin combined with valsartan for patients with chronic nephritis

目的探索阿托伐他汀联合缬沙坦治疗慢性肾炎患者的临床有效率。方法选择2016年2月至2018年2月在本院就诊的慢性肾炎患者100例为研究对象,实施信封随机分组模式分为对照组与观察组,每组50例,分别给予缬沙坦、阿托伐他汀联合缬沙坦治疗,比较两组肾功能指标、24h尿蛋白定量、血脂数据、炎症因子水平。结果观察组患者肾功能指标、24h尿蛋白定量、总胆固醇、三酰甘油、低密度脂蛋白均低于对照组,高密度脂蛋白高于对照组,炎症因子水平优于对照组,均P<0.05。结论阿托伐他汀联合缬沙坦治疗慢性肾炎效果较佳,可推广。

Objective To explore the clinical efficacy of atorvastatin combined with valsartan in the treatment of patients with chronic nephritis. Methods Patients with chronic nephritis who were treated at our hospital from February, 2016 to February, 2018 were selected as study objects, and were randomly divided into a control group and an observation group, 50 cases for each group. The control group were treated with valsartan, and the observation group with valsartan and atorvastatin. The renal function indicators, 24 h urine protein quantitation, blood lipid data, and inflammatory factors were compared between these two groups. Results The renal function indicators, 24 h urine protein quantitation, total cholesterol, triglyceride, and low density lipoprotein were lower, the high density lipoprotein was higher, and the inflammatory factor levels were better in the observation group than in the control group (P < 0.05). Conclusion Atorvastatin combined with valsartan is effective in the treatment of chronic nephritis.