IGF-2在结直肠癌组织中的表达及临床意义

Expression of IGF-2 in colorectal cancer and its clinical significance

目的探讨胰岛素样生长因子2(IGF-2)在结直肠癌组织中的表达及临床意义。方法选取79例病理学检查确诊为结直肠癌的患者,获取其肿瘤组织标本,采用qRT-PCR、免疫组化染色分别检测结直肠癌组织中IGF-2 mRNA及蛋白表达。结果结直肠癌组织中IGF-2 mRNA、蛋白表达与TMN分期有关,即分期越高,mRNA及蛋白表达越强,差异均有统计学意义(均P<0.05);结直肠癌组织中IGF-2 mRNA、蛋白表达与患者年龄、性别、BMI、肿瘤部位均无关,差异均无统计学意义(均P>0.05)。结论IGF-2可能参与结直肠癌的发生、发展。

Objective To explore the expression and clinical significance of insulin-like growth factor 2(IGF-2) in patients with colorectal cancer. Methods Seventy-nine patients with colorectal cancer admitted in Huzhou Central Hospital fromJanuary 2017 to May 2018 were recruited. The tumor tissue samples of colorectal cancer patients were obtained, and the expression of IGF-2 mRNA and protein in tumor tissues were detected by qRT-PCR and immunohistochemical staining, respectively. Results The expression of IGF-2 mRNA and protein in colorectal cancer was correlated with TMN staging(all P<0.05), but not correlated with patients' age, gender, BMI and tumor site(all P >0.05). Conclusion IGF-2 may be involved in the occurrence and development of colorectal cancer.