高龄备孕妇女人乳头状瘤病毒感染现状调查分析

Investigation and Analysis of the Status of Papilloma Virus Infection in Women with Advanced Pregnancy Preparation

目的了解高龄备孕妇女生殖道人乳状瘤病毒(HPV)感染现状,探讨这一人群HPV感染相关的危险因素。方法选择深圳市福田区妇幼保健院孕前保健门诊2017年8月—2018年8月期间就诊的732例高龄备孕妇女为研究对象,对其宫颈分泌物进行21种HPV基因型检测,并对其HPV感染的相关危险因素进行调查分析。结果732例高龄备孕妇女HPV感染率为9.02%,其HPV感染亚型以52型、16型、58型及68型为主;处于育龄阶段的备孕妇女HPV感染率与年龄无显著相关;高龄备孕妇女HPV感染与吸烟、使用避孕套、伴有生殖道其他感染、丈夫阴茎包皮过长等有密切关联。结论吸烟、使用避孕套、伴有生殖道其他感染、丈夫阴茎包皮过长是高龄备孕妇女HPV感染的危险因素。

Objective To investigate the status of human papilloma virus(HPV)infection in reproductive tract of pregnant women, and to explore the risk factors associated with HPV infection in this population. Method 732 pregnant women in Futian District of Shenzhen City from August,2017 to August,2018 were selected as subjects to detect 21 kinds of HPV genotypes in cervical secretions from the pre-pregnancy care clinic of Futian District,Shenzhen City. The risk factors of HPV infection were investigated and analyzed. Results The infection rate of HPV in 732 pregnant women was 9.02%,and the subtype of HPV infection was 52,16,58,68 type. There was no significant correlation between HPV infection rate and age in pregnant women of childbearing age. HPV infection is closely associated with smoking,condom use,other genital tract infections and long penile prepuce in older pregnant women. Conclusion Smoking,condom use,other genital tract infections and long prepuce of husband’s penis are independent risk factors for HPV infection in older pregnant women.