ATR在浸润性乳腺癌组织中的表达和临床意义

Expression of ATR in invasive ductal breast cancer tissues and its clinical significance

目的:探讨共济失调毛细血管扩张突变基因Rad3相关蛋白(ATR)在浸润性乳腺癌组织中的表达及其临床意义。方法:收集289例乳腺癌改良根治术后病理标本,构建组织芯片,采用免疫组化方法检测组织中ATR的表达,并分析其与临床病理参数之间的关系。结果:ATR在乳腺癌组织中的阳性表达率为70.6%(204/289)。ATR阳性表达率在肿瘤直径>2 cm组高于≤2 cm组,在TNM分期Ⅱ-Ⅲ期组高于I期组,在孕激素受体(PR)阳性组高于PR阴性组,在人类表皮生长因子受体2(HER-2)阳性组高于HER-2阴性组,在非三阴性乳腺癌组高于三阴性乳腺癌组,差异均有统计学意义(P<0.05);ATR的表达与患者发病年龄、月经状态、组织学分级、淋巴结转移情况、雌激素受体(ER)水平、p53状态无明显相关(P>0.05)。结论:浸润性乳腺癌组织中ATR的高表达可能与乳腺癌的进展相关。

Objective:To investigate protein expression of ATR(ataxia telangiectasia mutated and Rad3 related protein) in invasive ductal breast cancer tissues and the relevant clinical significance.Methods:Totally 289 cases of invasive ductal breast cancer tissue were collected to construct tissue microarrays.Immunohistochemistry was used to detect protein expression of ATR.The correlation between protein expression and clinicopathological parameters was explored.Results:The positive rate of ATR in breast cancer tissues was 70.6%(204/289).The protein expression was significantly higher in the cases with tumor size>2 cm,TNM stageⅡ-Ⅲ,PR-positive,HER-2-positive and non-triple-negative breast cancer(P<0.05).No statistically significant difference was found in ATR expression according to different ages,menopausal status,histological grade,regional lymph node metastasis,ER and p53 status.Conclusion:Detection of ATR protein expression by immunohistochemistry may help to investigate the biological behavior of the breast cancer.