类风湿关节炎患者并发骨质疏松症的危险因素调查

Investigation on risk factors of rheumatoid arthritis patients complication with osteoporosis

目的探讨类风湿关节炎(RA)患者并发骨质疏松症(OP)的相关危险因素,为早期预防OP提供依据。方法回顾性选取420例RA患者,依据是否并发OP将患者分为OP组(78例)和非OP组(342例);采用单因素比较法和多因素logistic回归法分别筛选影响RA并发OP的相关危险因素。结果 420例住院RA患者中的OP发生率为18.6%(78/420);多因素分析结果显示,年龄(OR=2.200)、病程(OR=2.591)、累及关节数(OR=4.855)、Sharp评分(OR=5.427)、骨侵蚀评分(OR=6.377)及ESR(OR=3.667)等均为并发OP的危险因素。结论 RA患者具有较高的OP发生率,应针对以上高危因素早期采取预防措施,降低并发OP和骨折的发生率,改善RA患者的预后。

Objective To explore the correlated risk factors of rheumatoid arthritis (RA) patients complicated with osteoporosis (OP), and provide basis for preventing OP. Methods Retrospectively 420 cases of RA were chosen and divided into the OP group (78 cases) and the the non-OP group (342 cases) according to with or without complication with OP. The correlated risk factors of RA complication with RA were respectively screened by single comparison method and multiple factors logistic regression method. Results The incidence rate of OP in RA patients within hospitalization was 18.6%(78/420). Multiple factors analysis result showed that the risk factors of RA complicated with OP included age ( OR =2.200), course of disease ( OR =2.591), number of joints involved (OR= 4.855), Sharp score ( OR =5.427), bone erosion score ( OR =6.377) and ESR ( OR =3.667). Conclusion RA patients have a high incidence rate of OP. To aim directly at these above high risk factors, we should early adopt prevention measures to cut down the incidence rates of OP and fracture, and improve the prognosis of RA patients.