盐酸西替利嗪联合孟鲁斯特钠治疗慢性荨麻疹的疗效观察及机制分析

Therapeutic Effect and Mechanism Analysis of Cetirizine Hydrochloride Combined with Montelukast Sodium in the Treatment of Chronic Urticaria

目的探讨盐酸西替利嗪联合孟鲁斯特钠治疗慢性荨麻疹的临床疗效及对血清中干扰素-r(IFN-r)、白细胞介素-4(IL-4)及总IgE水平的影响。方法方便选取入组的120例慢性荨麻疹患者,采用随机数字表法分成治疗组和对照组,各60例。治疗组口服盐酸西替利嗪片10 mg/次(1次/d)及孟鲁司特钠片10 mg/次(1次/d),对照组仅予口服盐酸西替利嗪片10 mg/次(1次/d),两组患者连续治疗8周。结果治疗组的有效率为91.7%,显著高于对照组的有效率71.7%(P<0.05)。治疗组复发率为15.6%,明显低于对照组复发率36.4%(P<0.05)。治疗后两组患者的IL-4、总IgE水平均较治疗前显著降低(P<0.05),而IFN-r水平较治疗前有明显升高(P<0.05)。均未出现严重不良反应。结论盐酸西替利嗪联合孟鲁斯特钠治疗慢性荨麻疹疗效优于单用盐酸西替利嗪,安全性好,并能降低复发率;降低血清中IL-4及血清总IgE水平,升高IFN-r水平可能是其作用机制之ー。

Objective To investigate the clinical efficacy of cetirizine hydrochloride combined with montelukast sodium in the treatment of chronic urticaria and its effect on serum levels of Interferon-r (IFN-r), Interleukin-4 (IL-4) and total IgE. Methods Convenient select 120 patients with chronic urticaria were randomly divided into treatment group and control group with 60 cases in each group. The treatment group was given cetirizine hydrochloride tablets 10 mg/time (once a day) and montelukast sodium tablets 10 mg/time (once a day), while the control group was given cetirizine hydrochloride tablets 10 mg/time (once a day). The two groups were treated continuously for 8 weeks. Results The effective rate of the treatment group was 91.7%, which was significantly higher than that of the control group 71.7%(P < 0.05). The recurrence rate of the treatment group was 15.6%, significantly lower than that of the control group 36.4%(P<0.05). After treatment, the levels of IL-4 and total IgE in both groups were significantly lower than those before treatment (P < 0.05), while the levels of IFN-r were significantly higher than those before treatment (P < 0.05). No serious adverse reactions were observed. Conclusion Cetirizine hydrochloride combined with montelukast sodium is superior to cetirizine hydrochloride alone in the treatment of chronic urticaria. It is safe and can reduce the recurrence rate. Reducing the serum levels of IL-4 and total IgE and increasing the level of IFN-r may be its mechanism.