骨转换标记物与2型糖尿病微血管并发症的关系

RELATIONSHIPS BETWEEN BONE TURNOVER MARKERS AND DIABETIC MICROVASCULAR COMPLICATIONS IN TYPE 2 DIABETES MELLITUS

目的:探讨骨转换标志物与2型糖尿病合并微血管并发症的关系。方法:146例2型糖尿病患者根据是否合并糖尿病微血管并发症分为实验组和对照组,实验组77例患者,合并糖尿病肾病和/或糖尿病视网膜病变,对照组69例患者,未合并糖尿病肾病和/或糖尿病视网膜病变。分别记录两组患者的一般资料,检测两组患者的血生化指标和骨转换标志物。结果:实验组患者的病程明显长于对照组(P<0.05);实验组患者血清羧基末端胶原交联肽(CTX)明显高于对照组,骨钙素(OC)明显低于对照组(P<0.05)。Logistic回归分析显示,CTX、病程是2型糖尿病合并微血管病变的危险因素,OC是2型糖尿病合并微血管病变的保护因素。结论:骨转换标记物CTX、OC与2型糖尿病患者微血管并发症发生风险有关,二者有望成为监测2型糖尿病患者微血管病变及骨代谢变化的标记物。

Objective:To investigate the relationships between bone turnover markers and diabetic microvascular complications in type 2 diabetes mellitus.Methods:146 type 2 diabetes mellitus patients were divided into experimental group(77 patients,complicated with diabetic nephropathy and/or diabetic retinopathy)and control group(69 patients,no diabetic microvascular complications).The general informations of patients in 2 groups were recorded;and the blood biochemical indicators and bone turnover markers of patients were detected.Results:The course of disease of patients in experimental group was remarkably longer than control group(P<0.05);the carboxy-terminal collagen crosslinks(CTX)of patients in experimental group was remarkably higher than control group,the osteocalcin(OC)was remarkably lower(P<0.05).Logistic regression analysis showed that CTX and course of disease were risk factors of type 2 diabetes mellitus with microangiopathy,OC was protective factor.Conclusions:Bone turnover markers CTX and OC are associated with the risk of microvascular complications in patients with type 2 diabetes mellitus,which are expected to be markers for monitoring microangiopathy and bone metabolism in patients with type 2 diabetes mellitus.