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丝胶对2型糖尿病大鼠胰腺Akt的调节作用 被引量:1

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摘要 2型糖尿病是一种由胰岛素相对或绝对分泌不足导致的以血糖升高为主要临床表现的代谢性疾病。在胰腺,胰岛素由胰岛β细胞分泌后与胰岛素受体(insulin receptor,IR)结合而启动磷脂酰肌醇-3-激酶/蛋白激酶B(phos-phatidylinodtol-3—kinase/protein kinase B,PI3K/Akt)信号通路,启动后的PDK/Akt信号通路通过调控胰岛素分泌,维持β细胞的生长、增殖等途径来实现胰岛素降低血糖的作用[1-2]。
出处 《承德医学院学报》 2019年第3期254-256,共3页 Journal of Chengde Medical University
基金 国家自然科学基金资助项目(81441133) 河北省自然科学基金资助项目(H2013406096) 河北省重点学科建设项目资助(冀教高[2013]4号"人体解剖与组织胚胎学")
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