妊娠合并亚甲减孕妇分娩方式对新生儿甲状腺素的影响

The Effect of Delivery Mode on Neonatal Thyroxine in Pregnant Women with Subclinical Hypothyroidism During Pregnancy

目的探讨妊娠合并亚临床甲状腺功能减退孕妇的分娩方式对新生儿甲状腺素的影响。方法随机选择妊娠合并亚临床甲状腺功能减退孕妇活产的足月新生儿107例,包括平产76例,剖宫产31例。测定其脐带血促甲状腺素(thyrotropin,TSH)、总三碘甲腺原氨酸(total triiodothyronine,TT3)和总甲状腺素(total thyroxine,TT4)水平并统计分析。结果妊娠合并亚临床甲状腺功能减退孕妇平产和剖宫产的新生儿脐带血TSH水平的差异有统计学意义(P<0.05),TT3和TT4水平的差异均无统计学意义(P>0.05)。结论剖宫产娩出胎儿未受宫缩及产道挤压的影响,其脐带血TSH水平较平产儿低。

Objective To further improve the screening method of neonatal thyroid function.Methods This study recruited one hundred and seven cases of neonatus who were delivered by pregnant women with subclinical hypothyroidism during pregnancy.Seventy six of them were natural labor,and thirty one of them were cesarean delivery.The concentrations of umbilical cord blood thyrotropin(TSH),total triiodothyronine(TT3 )and total thyroxine(TT4 )were detected and compared between the two groups.Results The statistical analysis showed that there was significant difference of umbilical cord blood TSH between the natural labor and delivered neonatus(P<0.05),and there were no significant differences of umbilical cord blood TT3,umbilical cord blood TT4 and birth weight between the two groups(P>0.05).Conclusion The fetus of cesarean section is not affected by uterine contractions and birth canal extrusion,and the level of TSH in cord blood is lower than that in normal infants.