棘白霉素B母核在低级醇-丙酮体系中的纯化研究

Purification of Echinocandin B Nucleus in the Mixture of Lower Alkanol and Acetone

棘白霉素B母核(ECBN)结晶纯化是提取步骤中最为重要的一个步骤,通过实验,摸索出了ECBN的最佳结晶条件,乙醇/丙酮为最优纯化体系,当混合液中乙醇含量为4%~5%,混合液用量为浓缩液的10~14倍体积时,棘白霉素B母核有很好的纯化效果和较高的收率。

Purification of echinocandin B nucleus is a important extraction process. The mixture of ethanol and acetone was the optimum crystallization condition and when the ethanol content was 4%~5%, the mixture consumption was 10~14 times of the concentrate echinocandin B nucleus has good purification effect and high yield.