阿昔洛韦治疗小儿传染性单核细胞增多症的临床价值分析

Analysis on clinical value of acyclovir in the treatment of Children with infectious mononucleosis

目的观察小儿传染性单核细胞增多症患儿采取阿昔洛韦治疗的临床价值分析。方法将在我院2016年1月~2018年9月收治的传染性单核细胞增多症患儿52例按照随机数字表法分成实验组26例与对照组26例。其中采取阿昔洛韦治疗的为实验组,采取头孢类治疗的为对照组。比较两组患者的临床治疗效果、不良反应发生率、治疗后3d平均体温与白细胞计数、平均症状消失时间、平均住院时间等情况。结果实验组患者临床总有效率为96.15%,不良反应率为7.69%,对照组患者临床总有效率为76.92%,不良反应率为30.77%,差异有统计学意义(P <0.05)。治疗后3d实验组患者平均体温、白细胞计数、症状消失时间、平均住院时间明显少于对照组,差异有统计学意义(P <0.01)。结论在小儿传染性单核细胞增多症患儿的治疗中,采取阿昔洛韦治疗,可有效缩短症状持续时间,平稳降低体温与白细胞计数,缩短住院时间,提高临床治疗效果,降低并发症的发生,效果理想。

Objective To observe the clinical value of acyclovir in the treatment of children with infectious mononucleosis. Methods 52 children who were diagnosed with infectious mononucleosis and treated in our hospital from January 2016 to September 2018 were selected and they were divided into the experimental group(26 cases) and the control group(26 cases) according to random number table method.The experimental group was given acyclovir and the control group was given cephalosporin.The clinical curative effect,the incidence of adverse reactions,the average body temperature and white blood cell count of 3 days after treatment,the average disappearance time of symptoms and the average hospitalization stay were compared between the two groups. Results The total effective rate and adverse reaction rate of the experimental group were respectively 96.15% and 7.69%.Those of the control group were respectively 76.92% and 30.77%.The difference was statistically significant(P < 0.05).The average body temperature of 3 days after treatment,white blood cell count, the disappearance time of symptoms and the average hospitalization stay in the experimental group were significantly less than those in the control group. The differences were statistically significant(P < 0.01). Conclusion In treatment of children with infectious mononucleosis,acyclovir an effectively shorten the duration of symptoms,smoothly lower the body temperature and the while cell count,shorten the hospital stay,improve the clinical curative effect and reduce the occurrence of complications,and its effect is ideal.