纤维样肾小球病1例报道及文献回顾

A case report of fibroid glomerulopathy and literature review

纤维样肾小球病(FGP)是临床上罕见的一类原发性肾小球疾病,临床表现为大量蛋白尿、镜下血尿、高血压等。电镜为确诊该病的主要依据,其镜下表现为纤维样物质(直径15~20mm)弥漫性或团块状分布于肾小球系膜区和(或)基底膜区。FGP多好发于中年男性且预后不良。现将我科2018年7月经电镜确诊为FGP患者1例,结合相关文献,就其主要病理改变、临床表现及鉴别诊断报道如下。

Fibrillaryglomerulopathy(FGP) is a rare type of primary glomerular disease in clinical practice. The clinical manifestations are massive proteinuria, microscopic hematuriaand hypertension. Electron microscopy is the main basis for the diagnosis of this disease, which is characterized by the diffuse or massive distribution of fibrous substances(diameter 15-20 mm) in the mesangial area and/or basement membrane area under the microscope. FGP mostly occurs in middle-aged men and the prognosisis poor. A case of FGP diagnosed by electron microscopy in our department in July 2018 is reported as follows on its main pathological changes, clinical manifestations and differential diagnosis combined with relevant literature.