白介素-6在HIV合并马尔尼菲蓝状菌感染人群中的表达及作用初步研究

The expression and effect of IL-6 in HIV and Talaromyces marneffei coinfection patients

目的探讨白介素-6(interleukin 6,IL-6)在人类免疫缺陷病毒(human immunodeficiency virus,HIV)合并马尔尼菲蓝状菌(talaromyces marneffei,TM)感染人群中的表达情况及作用。方法选择在南宁市第四人民医院未接受抗病毒治疗(antiretroviral therapy,ART)的HIV感染者27例,按是否合并TM感染情况分为HIV+TM组(12例)与HIV组(15例)。比较两组的人口学资料和外周血单核细胞(peripheral blood mononuclear cell,PBMC)中IL-6的表达水平。结果两组年龄、性别和病毒载量比较差异无统计学意义(P> 0.05),HIV+TM组的CD4^+T细胞计数低于HIV组,差异有统计学意义(P=0.018)。HIV+TM组中巨噬细胞(PBMC中的一个亚群)的IL-6表达水平高于HIV组,差异有统计学意义(P=0.039)。结论 HIV+TM组PBMC中的IL-6表达较HIV组高,这可能是导致巨噬细胞免疫过度激活,促进TM感染,影响病程进展的关键因素。

Objective To explore the expression and effect of interleukin 6(IL-6) in human immunodeficiency virus(HIV) and Talaromyces marneffei(TM) coinfection patients. Methods Twenty-seven HIV-infected patients who had not received antiretroviral therapy(ART) were selected from the Fourth People′s Hospital of Nanning City, and were divided into HIV+TM group(12 cases) and HIV group(15 cases) according to the infection status of TM. The demographic data and the level of IL-6 in perpheral blood mononuclear cell(PBMC) were compared between the two groups. Results There were no significant differences in age, gender and viral load between the two groups( P >0.05), while the CD4 + T cell count of the HIV+TM group was significantly lower than that of the HIV group( P =0.018). The IL-6 expression level of macrophages(a subgroup of PBMC) in the HIV+TM group was significantly higher than that of the HIV group( P =0.039). Conclusion The IL-6 expression of HIV+TM group in PBMC is higher than HIV group, which may lead to immune hyperactivation in macrophages and may be a critical factor to promote TM infection and disease progression.