肝内胆管癌常见分型方法及诊治回顾

Retrospect of common typing methods and diagnosis and treatment of intrahepatic cholangiocarcinoma

肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)的分型,通常根据解剖位置、生长方式、微观特征和细胞起源等进行。近来,依据组织学特征和细胞起源,ICC被分为胆管型和细胆管型两种亚型。几种常用的ICC的分型包括块状型、管周浸润型及管内生长型等,其中胆管型ICC肿瘤细胞富含黏蛋白,细胞基质丰富,S100P和TFF1多呈阳性,而细胆管型ICC肿瘤细胞内,无黏蛋白,CD56、N-钙黏蛋白以及CRP多呈阳性。

The various classification schemes of intrahepatic cholangiocarcinoma (ICC) based on anatomic location, macroscopic growth pattern,microscopic features,and cell of origin are out-lined.Until recently,ICC were classified into two subtypes,bile duct type and cholangiolar type based on histological features and cell of origin. Some classifications of ICC include mass forming,periductal infiltrating,and intraductal.Tumor cells of bile duct type ICC contain mucin and abundant desmoplastic stroma,and are often positive for S100P and TFF1,which of cholangiolar type ICC contain no mucin,and are often positive for CD56,N-cadherin and CRP.