胃型宫颈腺癌中免疫组织化学的研究进展

Progress of immunohistochemistry in gastric-type endocervical adenocarcinoma

胃型宫颈腺癌(gastric-type endocervical adenocarcinoma,GAS)是一种罕见类型的宫颈黏液腺癌,发病率仅占宫颈腺癌的1%~3%。因该肿瘤临床表现缺乏特异性及组织病理学特征类似良性病变,给病理诊断,尤其是早期的病理诊断带来了很大的挑战,易漏诊、误诊。但该肿瘤却具有高度恶性的生物学行为,因此很大一部分患者直到广泛转移才得以确诊,导致治疗延误,严重影响预后。免疫组织化学标志物是GAS诊断、鉴别诊断及治疗的关键。

Gastric-type endocervical adenocarcinoma (GAS) is a rare type of cervical mucinous adenocarcinoma,and its incidence rate is only 1%-3% of cervical adenocarcinoma.Due to the lack of specificity in clinical manifestations and histopathological features of the tumor similar to benign lesions,it brings great challenges to pathological diagnosis,especially early pathological diagnosis.It is easy to miss and misdiagnose,but the tumor has highly malignant biological behavior.Therefore,a large proportion of patients are not diagnosed until extensive metastasis,resulting in treatment delay and serious impact on prognosis.Immunohistochemical markers are the key to GAS diagnosis,differential diagnosis and treatment.