氧驱雾化吸入普米克令舒治疗哮喘急性发作患儿肺功能的影响

Effect of Oxygen Flooding Inhalation of Pulmicort Respules on Pulmonary Function in Children with Acute Asthma Attack

目的探讨哮喘急性发作患儿应用氧驱雾化吸入普米克令舒对其肺功能及临床疗效的影响。方法选取该院于2017年4月—2018年9月收治的84例哮喘急性发作患儿,将其随机分为对照组与观察组,各组42例。其中对照组予以常规治疗,观察组则在对照组的基础上加以氧驱雾化吸入普米克令舒的治疗方式,对比两组患儿的临床疗效以及肺功能指标的改善情况。结果观察组临床治疗总有效率为92.9%,对照组为71.4%,观察组总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患儿治疗前FVC、FEV_1以及PEF分别为(1.05±0.27)L、(1.59±0.51)L、(165.75±24.18)L/min,对照组患儿治疗前FVC、FEV_1以及PEF分别为(1.03±0.28)L、(1.57±0.46)L、(165.39±23.62)L/min,观察组与对照组患儿治疗前FVC、FEV_1以及PEF比较,差异无统计学意义(t=0.333 2,0.188 7,0.069 0;P>0.05)。观察组患儿治疗后FVC、FEV_1以及PEF分别为(1.95±0.46)L、(2.84±0.57)L、(198.32±30.43)L/min,对照组患儿治疗后FVC、FEV_1以及PEF分别为(1.36±0.32)L、(2.14±0.47)L、(179.26±31.05)L/min,观察组患儿治疗后FVC、FEV_1以及PEF明显高于对照组,差异有统计学意义(t=6.823 5,6.140 5,2.841 2;P<0.05)。结论针对哮喘急性发作患儿的治疗过程中,在常规治疗的基础下,加以氧驱雾化吸入普米克令舒的治疗方式可显著提升患儿的治疗效率,加快临床各项指标的消失时间,促进患儿肺功能指标的改善程度,值得临床借鉴实施。

Objective To investigate the effect of inhalation of Pulmicort Respules on the pulmonary function and clinical efficacy of children with acute asthma attack. Methods Eighty-four children with acute asthma exacerbations were enrolled in our hospital from April 2017 to September 2018. They were randomly divided into control group and observation group, with 42 cases in each group. The control group received routine treatment, and the observation group was treated with oxygen-driven aerosol inhalation of Pulmicort Respules on the basis of the control group. The clinical efficacy and improvement of lung function index were compared between the two groups. Results The total effective rate was 92.9% in the observation group and 71.4% in the control group. The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05). The FVC, FEV1 and PEF of the observation group were(1.05±0.27)L,(1.59±0.51)L,(165.75±24.18)L/min, FVC, FEV1 and PEF in the control group were(1.03±0.28)L,(1.57±0.46)L, and(165.39±23.62)L/min, respectively. Compared with the control group, the pre-treatment FVC, FEV1 and PEF were compared. The difference was not statistically significant(t=0.333 2, 0.188 7, 0.069 0;P>0.05). The FVC, FEV1 and PEF of the observation group were(1.95±0.46)L,(2.84±0.57)L and(198.32±30.43)L/min, respectively. The FVC, FEV1 and PEF of the control group were(1.36±0.32)L,(2.14±0.47)L and(179.26±31.05)L/min, respectively. FVC, FEV1 and PEF were significantly higher in the observation group than in the control group,the difference was statistically significant(t=6.823 5, 6.140 5, 2.841 2;P<0.05). Conclusion In the treatment of children with acute asthma attack, under the conventional treatment, the treatment of oxygenation and inhalation of Pulmicort can significantly improve the treatment efficiency of children and accelerate the disappearance of clinical indicators, to promote the improvement of lung function indicators in children, it is worthy of clinical implementation.