恒清Ⅰ号方治疗血管性痴呆疗效观察

Observation of curative effect of Hengqing Ⅰ Decoction on vascular dementia

目的观察恒清Ⅰ号方治疗血管性痴呆患者的临床疗效。方法将94例血管性痴呆患者按照随机数字表法随机分为治疗组和对照组各47例。2组均给予拜阿司匹林(100 mg/次,每日1次)、立普妥(20 mg/次,每晚1次)口服,对伴发疾病给予相应治疗。在此基础上,治疗组给予恒清Ⅰ号方治疗,对照组给予尼莫地平(40 mg/次,每日3次)治疗,2组疗程均为3个月。观察2组患者治疗前后简易智力测定量表(MMSE)评分、长谷川痴呆量表(HDS)评分及日常生活能力评定量表(ADL)评分变化情况,并比较2组临床疗效。结果疗程结束后,对照组MMSE评分、HDS评分、ADL评分有增高趋势,但与治疗前比较差异均无统计学意义(P均>0.05);治疗组MMSE评分、HDS评分、ADL评分均明显高于治疗前及对照组(P均<0.05)。治疗组总有效率为80.85%,对照组总有效率为65.95%,治疗组总有效率明显高于对照组(P<0.05)。2组均无明显不良反应发生。结论恒清Ⅰ号方可以显著改善血管性痴呆患者的认知功能,疗效明显优于单纯西药治疗,且安全性良好。

Objective It is to observe the clinical curative effect of Hengqing ⅠDecoction in the patients with vascular dementia. Methods Ninety-four patients with vascular dementia were randomly assigned to treatment group and control group according to random number table. Both groups were given aspirin(100 mg/time, once per day) and Lipitor(20 mg/time, once every evening) by oral administration, and the complicating diseases were treated with corresponding therapy. On the basis of the above treatment, the treatment group was treated with Hengqing I decoction, and the control group was treated with nimodipine(40 mg/time, three times per day). Both groups were treated for 3 months. The changes of mini-mental state examination(MMSE) scores, Hastgawa dementia scale(HDS) scores and activity of daily living scale(ADL) scores before and after treatment were observed, and the clinical curative effect was evaluated in the two groups. Results After treatment, MMSE score, HDS scores and ADL scores in the control group showed a increase tendency, but compared with that before treatment, there was no significant difference(P>0.05);MMSE score, HDS scores and ADL scores in treatment group were significantly improved, which were significantly higher than that before treatment and in the control group(P<0.05). The total effective rate was 80.85% in the treatment group and 65.95% in the control group, the total effective rate in the treatment group was significantly higher than that in the control group(P<0.05). Conclusion Hengqing ⅠDecoction can significantly improve the cognitive function of patients with vascular dementia, and its curative effect is better than western medicine used alone, and its safety is good.